Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/75240
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Natal, Carolina M. | por |
dc.contributor.author | Fernandes, Maria José Gomes | por |
dc.contributor.author | Pinto, Nuno F. S. | por |
dc.contributor.author | Pereira, Renato B. | por |
dc.contributor.author | Vieira, Tatiana F. | por |
dc.contributor.author | Rodrigues, Ana Rita Oliveira | por |
dc.contributor.author | Pereira, David M. | por |
dc.contributor.author | Sousa, Sérgio F. | por |
dc.contributor.author | Fortes, A. Gil | por |
dc.contributor.author | Castanheira, Elisabete M. S. | por |
dc.contributor.author | Gonçalves, M. Sameiro T. | por |
dc.date.accessioned | 2022-01-06T11:54:04Z | - |
dc.date.available | 2022-01-06T11:54:04Z | - |
dc.date.issued | 2021-10-21 | - |
dc.identifier.citation | Natal, C. M., Fernandes, M. J. G., Pinto, N. F. S., Pereira, R. B., Vieira, T. F., Rodrigues, A. R. O., . . . T. Gonçalves, M. S. (2021). New carvacrol and thymol derivatives as potential insecticides: synthesis, biological activity, computational studies and nanoencapsulation. [10.1039/D1RA05616F]. RSC Advances, 11(54), 34024-34035. doi: 10.1039/d1ra05616f | por |
dc.identifier.issn | 2046-2069 | - |
dc.identifier.uri | https://hdl.handle.net/1822/75240 | - |
dc.description.abstract | New compounds with potential insecticide activity were synthesized by structural modifications performed in the monoterpenoids phenolic moieties of carvacrol and thymol, resulting in a set of derivatives with the ether function containing the propyl, chloropropyl or hydroxypropyl chains, as well as a bicyclic ether with an unsaturated chain containing a carboxylic acid terminal. In addition, an analogue of carvacrol and thymol isomers bearing methoxyl, 1-hydroxyethyl and (3-chlorobenzoyl)oxy, instead of the three original methyl groups, was also synthesized. Several structural changes that resulted in diminished insecticide activity have been identified, but two significantly active molecules have been synthesized, one of them being less toxic to human cells than the naturally-derived starting materials. Structured-based inverted virtual screening and molecular dynamics simulations demonstrate that these active molecules likely target the insect odorant binding proteins and/or acetylcholinesterase and are able to form stable complexes. For the most promising compounds, nanoencapsulation assays were carried out in liposomes of egg phosphatidylcholine/cholesterol (7:3) prepared by both thin film hydration and ethanolic injection methods. The compound-loaded liposomes were generally monodisperse and with sizes smaller or around 200 nm. The thin film hydration method allowed high encapsulation efficiencies (above 85%) for both compounds and a delayed release, while for the systems prepared by ethanolic injection the encapsulation efficiency is lower than 50%, but the release is almost complete in two days. | por |
dc.description.sponsorship | This study was funded by project PTDC/ASP-AGR/30154/2017 (POCI-01-0145-FEDER-030154) of the COMPETE 2020 program, co financed by the FEDER and the European Union. The authors acknowledge also to Foundation for Science and Technology (FCT, Portugal), and FEDER-COMPETE-QREN-EU for financial support to the research centres CQ-UM (UID/QUI/00686/2020), CF-UM-UP (UIDB/04650/2020) and REQUIMTE (UIDB/50006/2020). The NMR spectrometer Bruker Avance III 400 is part of the National NMR Network and was purchased within the framework of the National Program for Scientific Re-equipment, contract REDE/1517/RMN/2005 with funds from POCI 2010 (FEDER) and FCT. | por |
dc.language.iso | eng | por |
dc.publisher | Royal Society of Chemistry | por |
dc.relation | PTDC/ASP-AGR/30154/2017 | por |
dc.relation | UID/QUI/00686/2020 | por |
dc.relation | UIDB/04650/2020 | por |
dc.relation | UIDB/50006/2020 | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | por |
dc.subject | plant extracts | por |
dc.subject | nanoencapsulation | por |
dc.subject | biopesticides | por |
dc.subject | natural source | por |
dc.subject | computational studies | por |
dc.title | New carvacrol and thymol derivatives as potential insecticides: synthesis, biological activity, computational studies and nanoencapsulation | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://pubs.rsc.org/en/content/articlelanding/2021/RA/D1RA05616F | por |
oaire.citationStartPage | 34024 | por |
oaire.citationEndPage | 34035 | por |
oaire.citationIssue | 54 | por |
oaire.citationVolume | 11 | por |
dc.identifier.doi | 10.1039/D1RA05616F | por |
dc.subject.fos | Ciências Agrárias::Biotecnologia Agrária e Alimentar | por |
dc.subject.fos | Ciências Agrárias::Outras Ciências Agrárias | por |
dc.subject.fos | Ciências Naturais::Ciências Químicas | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | RSC Advances | por |
oaire.version | AM | por |
dc.subject.ods | Erradicar a fome | por |
dc.subject.ods | Produção e consumo sustentáveis | por |
dc.subject.ods | Proteger a vida terrestre | por |
Aparece nas coleções: | PHYSICS OF QUANTUM MATERIALS AND BIONANOSTRUCTURES (2018 - ...) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Highlighted revised manuscript_08-09-2021_SS_EC.pdf | Main document | 528,89 kB | Adobe PDF | Ver/Abrir |
1_Electronic Supplementary Information_15-07-2021_SS.pdf | Supplementary Information | 5,09 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons