Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/71981
Título: | Emerging biofabrication approaches for gastrointestinal organoids towards patient specific cancer models |
Autor(es): | Soto, Fernando Guimarães, Carlos F. Reis, R. L. Franco, Walfre Rizvi, Imran Demirci, Utkan |
Palavras-chave: | Bioengineering Externally driven assembly Organ on a chip Personalized medicine Self-assembly |
Data: | Abr-2021 |
Editora: | Elsevier 1 |
Revista: | Cancer Letters |
Citação: | Soto F., Guimarães C. F., Reis R. L., Franco W., Rizvi I., Demirci U. Emerging biofabrication approaches for gastrointestinal organoids towards patient specific cancer models, Cancer Letters, Vol. 504, pp. 116-124, doi:10.1016/j.canlet.2021.01.023, 2021 |
Resumo(s): | Tissue engineered organoids are simple biomodels that can emulate the structural and functional complexity of specific organs. Here, we review developments in three-dimensional (3D) artificial cell constructs to model gastrointestinal dynamics towards cancer diagnosis. We describe bottom-up approaches to fabricate close-packed cell aggregates, from the use of biochemical and physical cues to guide the self-assembly of organoids, to the use of engineering approaches, including 3D printing/additive manufacturing and external field-driven protocols. Finally, we outline the main challenges and possible risks regarding the potential translation of gastrointestinal organoids from laboratory settings to patient-specific models in clinical applications. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/71981 |
DOI: | 10.1016/j.canlet.2021.01.023 |
ISSN: | 0304-3835 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S0304383521000471 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20509-2021-cancer-letters-organoids.pdf | 2,22 MB | Adobe PDF | Ver/Abrir |