Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/71981
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Soto, Fernando | por |
dc.contributor.author | Guimarães, Carlos F. | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Franco, Walfre | por |
dc.contributor.author | Rizvi, Imran | por |
dc.contributor.author | Demirci, Utkan | por |
dc.date.accessioned | 2021-04-16T13:57:47Z | - |
dc.date.available | 2023-05-01T06:00:38Z | - |
dc.date.issued | 2021-04 | - |
dc.date.submitted | 2021-04 | - |
dc.identifier.citation | Soto F., Guimarães C. F., Reis R. L., Franco W., Rizvi I., Demirci U. Emerging biofabrication approaches for gastrointestinal organoids towards patient specific cancer models, Cancer Letters, Vol. 504, pp. 116-124, doi:10.1016/j.canlet.2021.01.023, 2021 | por |
dc.identifier.issn | 0304-3835 | por |
dc.identifier.uri | https://hdl.handle.net/1822/71981 | - |
dc.description.abstract | Tissue engineered organoids are simple biomodels that can emulate the structural and functional complexity of specific organs. Here, we review developments in three-dimensional (3D) artificial cell constructs to model gastrointestinal dynamics towards cancer diagnosis. We describe bottom-up approaches to fabricate close-packed cell aggregates, from the use of biochemical and physical cues to guide the self-assembly of organoids, to the use of engineering approaches, including 3D printing/additive manufacturing and external field-driven protocols. Finally, we outline the main challenges and possible risks regarding the potential translation of gastrointestinal organoids from laboratory settings to patient-specific models in clinical applications. | por |
dc.description.sponsorship | This work was supported by research funding provided by DoD grants (LC150650, W81XWH-16-1-0200) and (LC19029, W81XWH-20- 1-0746), NCI Center for Cancer Nano-technology Excellence for Trans lational Diagnostics (NCI– U54CA199075), NIH grant (R01 EB029805), the International Alliance for Cancer Early Detection (ACED) pilot award, and the Canary Center at Stanford for Cancer Early Detection Seed Award. F.S was supported by Stanford Molecular Imaging Scholars program, 5R25CA118681. (NIH T32 postdoctoral fellowship) and Schmidt Science Fellows. C.F.G acknowledges support from Fundaçao ˜ para a Ciˆencia e Tecnologia (Grant no. PD/BD/135253/2017), Fundaçao Luso-Americana para o Desenvolvimento (FLAD) and Stan ford RISE COVID-19 Crisis Response Faculty Seed Grant Program. I.R. acknowledges funding provided by the NC Translational and Clinical Sciences Institute (NCTraCS), supported by the National Center for Advancing Translational Sciences (NCATS, National Institutes of Healthh (NIH), through Grant Award Number UL1TR002489, and UNCNC State Joint BME Department Start-up Fund. F.S. and C.F.G. contributed equally to this work. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_NORTE/PD%2FBD%2F135253%2F2017/PT | - |
dc.rights | openAccess | por |
dc.subject | Bioengineering | por |
dc.subject | Externally driven assembly | por |
dc.subject | Organ on a chip | por |
dc.subject | Personalized medicine | por |
dc.subject | Self-assembly | por |
dc.title | Emerging biofabrication approaches for gastrointestinal organoids towards patient specific cancer models | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0304383521000471 | por |
dc.comments | http://3bs.uminho.pt/node/20509 | por |
oaire.citationStartPage | 116 | por |
oaire.citationEndPage | 124 | por |
oaire.citationVolume | 504 | por |
dc.date.updated | 2021-04-05T15:13:18Z | - |
dc.identifier.doi | 10.1016/j.canlet.2021.01.023 | por |
dc.identifier.pmid | 33577978 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Cancer Letters | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20509-2021-cancer-letters-organoids.pdf | 2,22 MB | Adobe PDF | Ver/Abrir |