Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/93040
Título: | Addressing the research and development gaps in modern phage therapy |
Autor(es): | Turner, Paul E. Azeredo, Joana Buurman, Ed. T. Green, Sabrina Haaber, Jakob Krause Haggstrom, Douglas Carvalho, Koichi Kameda de Figueiredo Kirchhelle, Claas Moreno, Mercedes Gonzalez Pirnay, Jean-Paul Portillo, Mirza Alas |
Palavras-chave: | antimicrobial resistance biofilm biotechnology patient access personalized medicine |
Data: | 18-Mar-2024 |
Editora: | Mary Ann Liebert |
Revista: | PHAGE: Therapy; Applications; and Research |
Citação: | Turner, P. E., Azeredo, J., Buurman, E. T., Green, S., Haaber, J. K., Haggstrom, D., … Portillo, M. A. (2024, March 1). Addressing the Research and Development Gaps in Modern Phage Therapy. Phage. Mary Ann Liebert Inc. http://doi.org/10.1089/phage.2023.0045 |
Resumo(s): | Antimicrobial resistance is on the rise globally, prompting increased research and development (R&D) of phage therapy as a strategy to address difficult-to-treat bacterial infections. We review the current state of phage therapy research, including major operational, epistemic, and biological challenges for phage R&D, and discuss some new approaches to developing the technology motivated by recent breakthroughs such as artificial intelligence and synthetic phage production. In addition, we contextualize these R&D challenges and opportunities in light of the ongoing predicament of commercial antimicrobial innovation and current publicprivate efforts to reinvigorate the pipeline of antimicrobial drug discovery. We conclude with reflections on the potential for new phage therapies to be readily accessible across all income contexts to better ensure broad patient access, and consider possible alternatives to current public and publicprivate solutions for phage therapy and production. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/93040 |
DOI: | 10.1089/phage.2023.0045 |
ISSN: | 2641-6530 |
e-ISSN: | 2641-6549 |
Versão da editora: | https://www.liebertpub.com/doi/10.1089/phage.2023.0045 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_57656_1.pdf | 208,09 kB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons