Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/93040
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Campo DC | Valor | Idioma |
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dc.contributor.author | Turner, Paul E. | por |
dc.contributor.author | Azeredo, Joana | por |
dc.contributor.author | Buurman, Ed. T. | por |
dc.contributor.author | Green, Sabrina | por |
dc.contributor.author | Haaber, Jakob Krause | por |
dc.contributor.author | Haggstrom, Douglas | por |
dc.contributor.author | Carvalho, Koichi Kameda de Figueiredo | por |
dc.contributor.author | Kirchhelle, Claas | por |
dc.contributor.author | Moreno, Mercedes Gonzalez | por |
dc.contributor.author | Pirnay, Jean-Paul | por |
dc.contributor.author | Portillo, Mirza Alas | por |
dc.date.accessioned | 2024-09-12T15:56:27Z | - |
dc.date.available | 2024-09-12T15:56:27Z | - |
dc.date.issued | 2024-03-18 | - |
dc.identifier.citation | Turner, P. E., Azeredo, J., Buurman, E. T., Green, S., Haaber, J. K., Haggstrom, D., … Portillo, M. A. (2024, March 1). Addressing the Research and Development Gaps in Modern Phage Therapy. Phage. Mary Ann Liebert Inc. http://doi.org/10.1089/phage.2023.0045 | por |
dc.identifier.issn | 2641-6530 | por |
dc.identifier.uri | https://hdl.handle.net/1822/93040 | - |
dc.description.abstract | Antimicrobial resistance is on the rise globally, prompting increased research and development (R&D) of phage therapy as a strategy to address difficult-to-treat bacterial infections. We review the current state of phage therapy research, including major operational, epistemic, and biological challenges for phage R&D, and discuss some new approaches to developing the technology motivated by recent breakthroughs such as artificial intelligence and synthetic phage production. In addition, we contextualize these R&D challenges and opportunities in light of the ongoing predicament of commercial antimicrobial innovation and current publicprivate efforts to reinvigorate the pipeline of antimicrobial drug discovery. We conclude with reflections on the potential for new phage therapies to be readily accessible across all income contexts to better ensure broad patient access, and consider possible alternatives to current public and publicprivate solutions for phage therapy and production. | por |
dc.description.sponsorship | Research reported in this publication is supported by CARB-X. CARB-X’s funding for this project is provided in part with federal funds from the U.S. Department of Health and Human Services, Administration for Strategic Preparedness and Response, BARDA, under agreement number: 75A50122C00028, and by an award from Wellcome (WT224842). K.K.F.C. was supported by PHAG-ONE (Agence Nationale de la Recherche). C.K. was supported by Wellcome Trust University Award (218118_Z_19_Z(2)). The contribution from M.G.M. to this project was made possible with funds from the Leibniz Competition, project T134/2022, of the Leibniz Association. | por |
dc.language.iso | eng | por |
dc.publisher | Mary Ann Liebert | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | antimicrobial resistance | por |
dc.subject | biofilm | por |
dc.subject | biotechnology | por |
dc.subject | patient access | por |
dc.subject | personalized medicine | por |
dc.title | Addressing the research and development gaps in modern phage therapy | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.liebertpub.com/doi/10.1089/phage.2023.0045 | por |
dc.comments | CEB57656 | por |
oaire.citationIssue | 1 | por |
oaire.citationVolume | 5 | por |
dc.date.updated | 2024-09-12T11:02:08Z | - |
dc.identifier.eissn | 2641-6549 | por |
dc.identifier.doi | 10.1089/phage.2023.0045 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
sdum.journal | PHAGE: Therapy; Applications; and Research | por |
oaire.version | VoR | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_57656_1.pdf | 208,09 kB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons