Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/91270
Título: | Silk fbroin/chitosan pH‑sensitive controlled microneedles |
Autor(es): | Jia, Tianshuo Kuang, Dajiang Qi, Zhenzhen Tan, Guohongfang Yang, Xiaojing Kundu, Subhas C Lu, Shenzhou |
Palavras-chave: | Chitosan Fibroin microneedles Glucose-responsive insulin Hydrogel |
Data: | Dez-2023 |
Editora: | Springer |
Revista: | Journal of Materials Science |
Citação: | Jia T., Kuang D., Qi Z., Tan G., Yang X., Kundu S. C., Lu S. Silk fibroin/chitosan pH-sensitive controlled microneedles, Journal of Materials Science, Vol. 58, Issue 46, pp. 17711–17725, doi:10.1007/s10853-023-09148-1, 2023 |
Resumo(s): | Silk fibroin is a widely used biocompatible medical material with tunable mechanical, degradability and environmental non-toxicity. This paper prepared the silk fibroin/chitosan hydrogel microneedle with pH sensitivity by blending silk fibroin with chitosan to induce graft cross-linking. The cross-linked silk fibroin/chitosan microneedles network is expanded by hydrogen ions and water molecules, forming a more significant swelling. In vitro, the transdermal drug release showed that insulin loaded in microneedles exhibited pH-sensitive drug release behavior and was released faster under acidic conditions than under neutral conditions. By changing the pH of the solution, microneedles can achieve a stimulating response to the environment, thereby intelligently regulating the transdermal release of insulin. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/91270 |
DOI: | 10.1007/s10853-023-09148-1 |
ISSN: | 0022-2461 |
e-ISSN: | 1573-4803 |
Versão da editora: | https://link.springer.com/article/10.1007/s10853-023-09148-1#article-info |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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21157-s10853-023-09148-1.pdf Acesso restrito! | 4,1 MB | Adobe PDF | Ver/Abrir |