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https://hdl.handle.net/1822/91270
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Campo DC | Valor | Idioma |
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dc.contributor.author | Jia, Tianshuo | por |
dc.contributor.author | Kuang, Dajiang | por |
dc.contributor.author | Qi, Zhenzhen | por |
dc.contributor.author | Tan, Guohongfang | por |
dc.contributor.author | Yang, Xiaojing | por |
dc.contributor.author | Kundu, Subhas C | por |
dc.contributor.author | Lu, Shenzhou | por |
dc.date.accessioned | 2024-04-23T15:10:14Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.citation | Jia T., Kuang D., Qi Z., Tan G., Yang X., Kundu S. C., Lu S. Silk fibroin/chitosan pH-sensitive controlled microneedles, Journal of Materials Science, Vol. 58, Issue 46, pp. 17711–17725, doi:10.1007/s10853-023-09148-1, 2023 | por |
dc.identifier.issn | 0022-2461 | por |
dc.identifier.uri | https://hdl.handle.net/1822/91270 | - |
dc.description.abstract | Silk fibroin is a widely used biocompatible medical material with tunable mechanical, degradability and environmental non-toxicity. This paper prepared the silk fibroin/chitosan hydrogel microneedle with pH sensitivity by blending silk fibroin with chitosan to induce graft cross-linking. The cross-linked silk fibroin/chitosan microneedles network is expanded by hydrogen ions and water molecules, forming a more significant swelling. In vitro, the transdermal drug release showed that insulin loaded in microneedles exhibited pH-sensitive drug release behavior and was released faster under acidic conditions than under neutral conditions. By changing the pH of the solution, microneedles can achieve a stimulating response to the environment, thereby intelligently regulating the transdermal release of insulin. | por |
dc.description.sponsorship | National Natural Science Foundation of China (Grant No. 51973144), Natural Science Research of Jiangsu Higher Education Institutions of China (Grant No. 20KJA540002), PAPD and Six Talent Peaks Project in Jiangsu Province (Grant No. SWYY-038) supported this work. | por |
dc.language.iso | eng | por |
dc.publisher | Springer | por |
dc.rights | restrictedAccess | por |
dc.subject | Chitosan | por |
dc.subject | Fibroin microneedles | por |
dc.subject | Glucose-responsive insulin | por |
dc.subject | Hydrogel | por |
dc.title | Silk fbroin/chitosan pH‑sensitive controlled microneedles | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://link.springer.com/article/10.1007/s10853-023-09148-1#article-info | por |
dc.comments | http://3bs.uminho.pt/node/21157 | por |
oaire.citationStartPage | 17711 | por |
oaire.citationEndPage | 17725 | por |
oaire.citationIssue | 46 | por |
oaire.citationVolume | 58 | por |
dc.date.updated | 2024-04-23T14:04:55Z | - |
dc.identifier.eissn | 1573-4803 | por |
dc.identifier.doi | 10.1007/s10853-023-09148-1 | por |
dc.date.embargo | 10000-01-01 | - |
sdum.journal | Journal of Materials Science | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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21157-s10853-023-09148-1.pdf Acesso restrito! | 4,1 MB | Adobe PDF | Ver/Abrir |