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https://hdl.handle.net/1822/85423
Título: | Anti-inflammatory effect of Pterospartum tridentatum leaf extract in acute and chronic inflammation |
Autor(es): | Laranjeira, Inês Martins Gonçalves, João N. D. Gonçalves, Cátia Silva, Marlene Mouta, Nuno Dias, Alberto C. P. Pinto-Ribeiro, Filipa |
Palavras-chave: | Pterospartum tridendatum Medicinal plants Bioactive compounds Acute inflammation Methanolic extracts Phytochemicals Experimental osteoarthritis Rat Hyperalgesia |
Data: | 1-Abr-2023 |
Editora: | Multidisciplinary Digital Publishing Institute |
Revista: | Applied Sciences |
Citação: | Laranjeira, I.M.; Gonçalves, J.N.D.; Gonçalves, C.; Silva, M.; Mouta, N.; Dias, A.C.P.; Pinto-Ribeiro, F. Anti-Inflammatory Effect of Pterospartum tridentatum Leaf Extract in Acute and Chronic Inflammation. Appl. Sci. 2023, 13, 4494. https://doi.org/10.3390/app13074494 |
Resumo(s): | Pterospartum tridendatum is an important source of active compounds with anti-inflammatory properties. The ability of P. tridentatum leaves methanolic extract in preventing/reversing inflammation was studied in adult rats using a model of experimental osteoarthritis (OA) and ear edema. Control animals (SHAM) were administered phosphate buffer solution (PBS), while OA animals received either P. tridentatum 100 mg/kg, 300 mg/kg, or a commercial anti-inflammatory (15 mg/Kg, Ibuprofen) via gavage, daily, for three weeks. Ear edema was induced, and the animals were divided into five groups treated with: (i) ethanol, (ii) P. tridentatum, (iii) croton oil, (iv) croton oil + P. tridentatum, and (v) croton oil + medrol. The inflammatory effect was evaluated by the measurement of the knee and ear edema. The chromatographic profile, evaluated by HPLC-DAD, showed numerous phenolic compounds are present. In the docking analysis of these compounds, isoquercetin demonstrated strong molecular interactions for peroxisome proliferator-activated receptor alpha and gamma (PPARα and PPARƴ, respectively), protein kinase 2 subunit α (CK2 α), and 5-lipoxygenase-activating proteins. Genistein had strong docking binding energies for CK2α and prostaglandin H (2) synthase-1. Our analysis showed the treatment with P. tridentatum extract reversed OA-induced edema in the rat knee, as well as ear edema, highlights this plant as a potential source of compounds that can be used as adjuvants in the management of inflammation. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/85423 |
DOI: | 10.3390/app13074494 |
e-ISSN: | 2076-3417 |
Versão da editora: | https://www.mdpi.com/2076-3417/13/7/4494 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
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Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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applsci-13-04494.pdf | 5,2 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons