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https://hdl.handle.net/1822/85423
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Campo DC | Valor | Idioma |
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dc.contributor.author | Laranjeira, Inês Martins | por |
dc.contributor.author | Gonçalves, João N. D. | por |
dc.contributor.author | Gonçalves, Cátia | por |
dc.contributor.author | Silva, Marlene | por |
dc.contributor.author | Mouta, Nuno | por |
dc.contributor.author | Dias, Alberto C. P. | por |
dc.contributor.author | Pinto-Ribeiro, Filipa | por |
dc.date.accessioned | 2023-07-06T16:19:20Z | - |
dc.date.available | 2023-07-06T16:19:20Z | - |
dc.date.issued | 2023-04-01 | - |
dc.identifier.citation | Laranjeira, I.M.; Gonçalves, J.N.D.; Gonçalves, C.; Silva, M.; Mouta, N.; Dias, A.C.P.; Pinto-Ribeiro, F. Anti-Inflammatory Effect of Pterospartum tridentatum Leaf Extract in Acute and Chronic Inflammation. Appl. Sci. 2023, 13, 4494. https://doi.org/10.3390/app13074494 | por |
dc.identifier.uri | https://hdl.handle.net/1822/85423 | - |
dc.description.abstract | Pterospartum tridendatum is an important source of active compounds with anti-inflammatory properties. The ability of P. tridentatum leaves methanolic extract in preventing/reversing inflammation was studied in adult rats using a model of experimental osteoarthritis (OA) and ear edema. Control animals (SHAM) were administered phosphate buffer solution (PBS), while OA animals received either P. tridentatum 100 mg/kg, 300 mg/kg, or a commercial anti-inflammatory (15 mg/Kg, Ibuprofen) via gavage, daily, for three weeks. Ear edema was induced, and the animals were divided into five groups treated with: (i) ethanol, (ii) P. tridentatum, (iii) croton oil, (iv) croton oil + P. tridentatum, and (v) croton oil + medrol. The inflammatory effect was evaluated by the measurement of the knee and ear edema. The chromatographic profile, evaluated by HPLC-DAD, showed numerous phenolic compounds are present. In the docking analysis of these compounds, isoquercetin demonstrated strong molecular interactions for peroxisome proliferator-activated receptor alpha and gamma (PPARα and PPARƴ, respectively), protein kinase 2 subunit α (CK2 α), and 5-lipoxygenase-activating proteins. Genistein had strong docking binding energies for CK2α and prostaglandin H (2) synthase-1. Our analysis showed the treatment with P. tridentatum extract reversed OA-induced edema in the rat knee, as well as ear edema, highlights this plant as a potential source of compounds that can be used as adjuvants in the management of inflammation. | por |
dc.description.sponsorship | This work was funded by ICVS Scientific Microscopy Platform, a member of the national infrastructure PPBI—Portuguese Platform of Bioimaging (PPBI-POCI-01-0145-FEDER-022122), by National funds, through the Foundation for Science and Technology (FCT)—project UIDB/50026/2020 and UIDP/50026/2020, and by the projects NORTE-01-0145-FEDER-000039 and NORTE-01-0145- FEDER-085468, supported by Norte Portugal Regional Operational Programme (NORTE 2020) under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). IL was supported by grants from FCT PhD programs (PD/BD/150263/2019). | por |
dc.language.iso | eng | por |
dc.publisher | Multidisciplinary Digital Publishing Institute | por |
dc.relation | PPBI-POCI-01-0145-FEDER-022122 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50026%2F2020/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50026%2F2020/PT | por |
dc.relation | NORTE-01-0145-FEDER-000039 | por |
dc.relation | NORTE-01-0145-FEDER-085468 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_NORTE/PD%2FBD%2F150263%2F2019/PT | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | Pterospartum tridendatum | por |
dc.subject | Medicinal plants | por |
dc.subject | Bioactive compounds | por |
dc.subject | Acute inflammation | por |
dc.subject | Methanolic extracts | por |
dc.subject | Phytochemicals | por |
dc.subject | Experimental osteoarthritis | por |
dc.subject | Rat | por |
dc.subject | Hyperalgesia | por |
dc.title | Anti-inflammatory effect of Pterospartum tridentatum leaf extract in acute and chronic inflammation | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/2076-3417/13/7/4494 | por |
oaire.citationIssue | 7 | por |
oaire.citationVolume | 13 | por |
dc.date.updated | 2023-04-12T13:24:20Z | - |
dc.identifier.eissn | 2076-3417 | - |
dc.identifier.doi | 10.3390/app13074494 | por |
dc.subject.fos | Ciências Médicas::Outras Ciências Médicas | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Applied Sciences | por |
oaire.version | VoR | por |
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applsci-13-04494.pdf | 5,2 MB | Adobe PDF | Ver/Abrir |
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