Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/85344
Título: | Encapsulation of vitamin D3 using rhamnolipids-based nanostructured lipid carriers |
Autor(es): | Azevedo, Maria A. Cerqueira, Miguel A. Gonçalves, Catarina Amado, Isabel R. Teixeira, José A. Pastrana, Lorenzo |
Palavras-chave: | Biosurfactant Emulsification Bioactive compounds Nanotechnology Nanoencapsulation |
Data: | 2023 |
Editora: | Elsevier 1 |
Revista: | Food Chemistry |
Citação: | Azevedo, Alexandra; Cerqueira, Miguel A.; Gonçalves, Catarina; Amado, I. R.; Teixeira, José A.; Pastrana, Lorenzo, Encapsulation of vitamin D3 using rhamnolipids-based nanostructured lipid carriers. Food Chemistry, 427(136654), 2023 |
Resumo(s): | This work had as main objective to encapsulate vitamin D3 (VD3) into nanostructured lipid carriers (NLCs) using rhamnolipids as surfactant. Glycerol monostearate and medium chain triglycerides with 2.625 % of VD3 were used as lipid materials. The three formulations of NLCs with VD3 (NLCs + VD3) were composed by 99 % of aqueous phase, 1 % of lipid phase and 0.05 % of surfactant. The difference between them was the ratio of solid:liquid in lipid phase. The NLCs + VD3 sizes ranged between 92.1 and 108.1 nm. The most stable formulation maintaining their caracteristics for 60 days at 4 °C. The NLCs + VD3 cytotoxicity demonstrated that concentrations of 0.25 mg/mL or lower up had a good biocompatibility in vitro. During the in vitro digestion, formulations with lower sizes and higher content on solid lipid had higher lipolysis rate and consequently higher VD3 bioaccessibility. The rhamnolipids-based NLCs are a good option for the encapsulation of VD3. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/85344 |
DOI: | 10.1016/j.foodchem.2023.136654 |
ISSN: | 0308-8146 |
Versão da editora: | http://www.elsevier.com/locate/issn/03088146 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_56310_1.pdf | 7,28 MB | Adobe PDF | Ver/Abrir |