Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/85344
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Campo DC | Valor | Idioma |
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dc.contributor.author | Azevedo, Maria A. | por |
dc.contributor.author | Cerqueira, Miguel A. | por |
dc.contributor.author | Gonçalves, Catarina | por |
dc.contributor.author | Amado, Isabel R. | por |
dc.contributor.author | Teixeira, José A. | por |
dc.contributor.author | Pastrana, Lorenzo | por |
dc.date.accessioned | 2023-07-04T15:58:32Z | - |
dc.date.available | 2023-07-04T15:58:32Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Azevedo, Alexandra; Cerqueira, Miguel A.; Gonçalves, Catarina; Amado, I. R.; Teixeira, José A.; Pastrana, Lorenzo, Encapsulation of vitamin D3 using rhamnolipids-based nanostructured lipid carriers. Food Chemistry, 427(136654), 2023 | por |
dc.identifier.issn | 0308-8146 | por |
dc.identifier.uri | https://hdl.handle.net/1822/85344 | - |
dc.description.abstract | This work had as main objective to encapsulate vitamin D3 (VD3) into nanostructured lipid carriers (NLCs) using rhamnolipids as surfactant. Glycerol monostearate and medium chain triglycerides with 2.625 % of VD3 were used as lipid materials. The three formulations of NLCs with VD3 (NLCs + VD3) were composed by 99 % of aqueous phase, 1 % of lipid phase and 0.05 % of surfactant. The difference between them was the ratio of solid:liquid in lipid phase. The NLCs + VD3 sizes ranged between 92.1 and 108.1 nm. The most stable formulation maintaining their caracteristics for 60 days at 4 °C. The NLCs + VD3 cytotoxicity demonstrated that concentrations of 0.25 mg/mL or lower up had a good biocompatibility in vitro. During the in vitro digestion, formulations with lower sizes and higher content on solid lipid had higher lipolysis rate and consequently higher VD3 bioaccessibility. The rhamnolipids-based NLCs are a good option for the encapsulation of VD3. | por |
dc.description.sponsorship | FCT -Fundação para a Ciência e a Tecnologia(UID/BIO/04469/2013) | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | (SFRH/BD/123364/2016) | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FBIO%2F04469%2F2013/PT | por |
dc.relation | (POCI-01- 0145-FEDER-006684) | por |
dc.relation | (NORTE-01-0145- FEDER-000004) | por |
dc.relation | NORTE-01-0145-FEDER-000047 | por |
dc.rights | openAccess | por |
dc.subject | Biosurfactant | por |
dc.subject | Emulsification | por |
dc.subject | Bioactive compounds | por |
dc.subject | Nanotechnology | por |
dc.subject | Nanoencapsulation | por |
dc.title | Encapsulation of vitamin D3 using rhamnolipids-based nanostructured lipid carriers | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.elsevier.com/locate/issn/03088146 | por |
dc.comments | CEB56310 | por |
oaire.citationIssue | 136654 | por |
oaire.citationConferencePlace | Netherlands | - |
oaire.citationVolume | 427 | por |
dc.date.updated | 2023-07-04T14:45:40Z | - |
dc.identifier.doi | 10.1016/j.foodchem.2023.136654 | por |
dc.identifier.pmid | 37399642 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
sdum.journal | Food Chemistry | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_56310_1.pdf | 7,28 MB | Adobe PDF | Ver/Abrir |