Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/85172
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Campo DC | Valor | Idioma |
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dc.contributor.author | Martins-Macedo, Joana | por |
dc.contributor.author | Mateus-Pinheiro, António | por |
dc.contributor.author | Alves, Cátia | por |
dc.contributor.author | Veloso, Fernando José Silva | por |
dc.contributor.author | Gomes, Eduardo D. | por |
dc.contributor.author | Ribeiro, Inês | por |
dc.contributor.author | Correia, Joana S. | por |
dc.contributor.author | Silveira-Rosa, Tiago | por |
dc.contributor.author | Alves, Nuno Dinis Lopes Oliveira | por |
dc.contributor.author | Rodrigues, Ana J. | por |
dc.contributor.author | Bessa, João M. | por |
dc.contributor.author | Sousa, Nuno | por |
dc.contributor.author | Oliveira, João F. | por |
dc.contributor.author | Patrício, Patrícia | por |
dc.contributor.author | Pinto, Luísa | por |
dc.date.accessioned | 2023-06-23T11:14:28Z | - |
dc.date.available | 2023-06-23T11:14:28Z | - |
dc.date.issued | 2023-01-20 | - |
dc.identifier.citation | Martins-Macedo, J.; Mateus-Pinheiro, A.; Alves, C.; Veloso, F.; Gomes, E.D.; Ribeiro, I.; Correia, J.S.; Silveira-Rosa, T.; Alves, N.D.; Rodrigues, A.J.; et al. StressMatic: A Novel Automated System to Induce Depressive- and Anxiety-like Phenotype in Rats. Cells 2023, 12, 381. https://doi.org/10.3390/cells12030381 | por |
dc.identifier.uri | https://hdl.handle.net/1822/85172 | - |
dc.description.abstract | Major depressive disorder (MDD) is a multidimensional psychiatric disorder that is estimated to affect around 350 million people worldwide. Generating valid and effective animal models of depression is critical and has been challenging for neuroscience researchers. For preclinical studies, models based on stress exposure, such as unpredictable chronic mild stress (uCMS), are amongst the most reliable and used, despite presenting concerns related to the standardization of protocols and time consumption for operators. To overcome these issues, we developed an automated system to expose rodents to a standard uCMS protocol. Here, we compared manual (uCMS) and automated (auCMS) stress-exposure protocols. The data shows that the impact of the uCMS exposure by both methods was similar in terms of behavioral (cognition, mood, and anxiety) and physiological (cell proliferation and endocrine variations) measurements. Given the advantages of time and standardization, this automated method represents a step forward in this field of preclinical research. | por |
dc.description.sponsorship | This research was funded by Bn’ML—Behavioral and Molecular Lab and by the National Strategic Reference Framework (QREN). L.P. and F.V. were funded by the Portuguese Foundation for Science and Technology (FCT) (2020.02855.CEECIND to L.P.; SFRH/BD/131545/2017 to F.V.). This work was funded by the Nature Research Award for Driving Global Impact—2019 Brain Sciences (to L.P.). J.F.O. received funding from FCT (projects PTDC/MED-NEU/31417/2017) and POCI-01-0145-FEDER-016818; grants from Bial Foundation (037/18) and ”la Caixa” Foundation (LCF/PR/HR21/52410024) to J.F.O. A.J.R. was funded by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement No 101003187), by “la Caixa” Foundation (ID 100010434), under the agreement LCF/PR/HR20/52400020, by FCT under the scope of the project PTDC/MED-NEU/4804/2020 (ENDOPIO). This work was also co-funded by the Life and Health Sciences Research Institute (ICVS); funded by ICVS Scientific Microscopy Platform, member of the national infrastructure PPBI—Portuguese Platform of Bioimaging (PPBI-POCI-01-0145-FEDER-022122); and funded by National funds, through the Foundation for Science and Technology (FCT)—project UIDB/50026/2020 and UIDP/50026/2020. | por |
dc.language.iso | eng | por |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | por |
dc.relation | info:eu-repo/grantAgreement/FCT/CEEC IND 3ed/2020.02855.CEECIND%2FCP1600%2FCT0006/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F131545%2F2017/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMED-NEU%2F31417%2F2017/PT | por |
dc.relation | POCI-01-0145-FEDER-016818 | por |
dc.relation | LCF/PR/HR21/52410024 | por |
dc.relation | LCF/PR/HR20/52400020 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMED-NEU%2F4804%2F2020/PT | por |
dc.relation | PPBI-POCI-01-0145-FEDER-022122 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50026%2F2020/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50026%2F2020/PT | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | Automated rack | por |
dc.subject | Stress-exposure | por |
dc.subject | Protocols standardization | por |
dc.subject | Preclinical research | por |
dc.title | StressMatic: a novel automated system to induce depressive- and anxiety-like phenotype in rats | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/2073-4409/12/3/381 | por |
oaire.citationStartPage | 1 | por |
oaire.citationEndPage | 12 | por |
oaire.citationIssue | 3 | por |
oaire.citationVolume | 12 | por |
dc.date.updated | 2023-02-10T14:29:03Z | - |
dc.identifier.eissn | 2073-4409 | - |
dc.identifier.doi | 10.3390/cells12030381 | por |
dc.identifier.pmid | 36766724 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Cells | por |
oaire.version | VoR | por |
dc.identifier.articlenumber | 381 | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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cells-12-00381.pdf | 4,06 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons