Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/82568
Título: | Childhood brain tumors: A review of strategies to translate CNS drug delivery to clinical trials |
Autor(es): | Rahman, Ruman Janowski, Miroslaw Killick-Cole, Clare L. Singleton, William G. B Campbell, Emma Walczak, Piotr Khatua, Soumen Faltings, Lukas Symons, Marc Schneider, Julia R. Kwan, Kevin Boockvar, John A. Gill, Steven S. Oliveira, Joaquim M. Beccaria, Kevin Carpentier, Alexandre Canney, Michael Pearl, Monica Veal, Gareth J. Meijer, Lisethe Walker, David A. |
Palavras-chave: | Brain Drugs Tumour Drug delivery Blood–brain barrier Brain tumor model Preclinical Xenograft Companion animal Childhood brain tumors Drug repurposing |
Data: | Jan-2023 |
Editora: | MDPI |
Revista: | Cancers |
Citação: | Rahman R., Janowski M., Killick-Cole C. L., Singleton W. G. B., Campbell E., Walczak P., Khatua S., Faltings L., Symons M., Schneider J. R., Kwan K., Boockvar J. A., Gill S. S., Oliveira J. M., k. Beccaria, Carpentier A., Canney M., Pearl M., Veal G. J., Meijer L., Walker D. A. Childhood brain tumors: A review of strategies to translate CNS drug delivery to clinical trials , Cancers, Vol. 15, Issue 3, pp. 857, doi:10.3390/cancers15030857, 2023 |
Resumo(s): | Brain tumors account for over 20% of childhood cancers and are the biggest cancer killer in children and young adults. Several initiatives over the past 40 years have tried to identify more effective drug treatments, but with very limited success. This is largely due to the bloodâ brain barrier, which restricts the entry of many drugs into the brain. In this review, we describe the main techniques that are being developed to enhance brain tumor drug delivery and explore the preclinical brain tumor models that are essential for translational development of these techniques. We also identify existing approved drugs that, if coupled with an efficient delivery method, could have potential as brain tumor treatments. Bringing this information together is part of a funded initiative to highlight drug delivery as a research strategy to overcome the current challenges for children diagnosed with brain tumors. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/82568 |
DOI: | 10.3390/cancers15030857 |
ISSN: | 2072-6694 |
Versão da editora: | https://www.mdpi.com/2072-6694/15/3/857 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20894-cancers-15-00857.pdf | 3,47 MB | Adobe PDF | Ver/Abrir |