Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/82568
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Rahman, Ruman | por |
dc.contributor.author | Janowski, Miroslaw | por |
dc.contributor.author | Killick-Cole, Clare L. | por |
dc.contributor.author | Singleton, William G. B | por |
dc.contributor.author | Campbell, Emma | por |
dc.contributor.author | Walczak, Piotr | por |
dc.contributor.author | Khatua, Soumen | por |
dc.contributor.author | Faltings, Lukas | por |
dc.contributor.author | Symons, Marc | por |
dc.contributor.author | Schneider, Julia R. | por |
dc.contributor.author | Kwan, Kevin | por |
dc.contributor.author | Boockvar, John A. | - |
dc.contributor.author | Gill, Steven S. | - |
dc.contributor.author | Oliveira, Joaquim M. | - |
dc.contributor.author | Beccaria, Kevin | - |
dc.contributor.author | Carpentier, Alexandre | - |
dc.contributor.author | Canney, Michael | - |
dc.contributor.author | Pearl, Monica | - |
dc.contributor.author | Veal, Gareth J. | - |
dc.contributor.author | Meijer, Lisethe | - |
dc.contributor.author | Walker, David A. | - |
dc.date.accessioned | 2023-02-08T16:31:38Z | - |
dc.date.available | 2023-02-08T16:31:38Z | - |
dc.date.issued | 2023-01 | - |
dc.date.submitted | 2023-02 | - |
dc.identifier.citation | Rahman R., Janowski M., Killick-Cole C. L., Singleton W. G. B., Campbell E., Walczak P., Khatua S., Faltings L., Symons M., Schneider J. R., Kwan K., Boockvar J. A., Gill S. S., Oliveira J. M., k. Beccaria, Carpentier A., Canney M., Pearl M., Veal G. J., Meijer L., Walker D. A. Childhood brain tumors: A review of strategies to translate CNS drug delivery to clinical trials , Cancers, Vol. 15, Issue 3, pp. 857, doi:10.3390/cancers15030857, 2023 | por |
dc.identifier.issn | 2072-6694 | por |
dc.identifier.uri | https://hdl.handle.net/1822/82568 | - |
dc.description.abstract | Brain tumors account for over 20% of childhood cancers and are the biggest cancer killer in children and young adults. Several initiatives over the past 40 years have tried to identify more effective drug treatments, but with very limited success. This is largely due to the bloodâ brain barrier, which restricts the entry of many drugs into the brain. In this review, we describe the main techniques that are being developed to enhance brain tumor drug delivery and explore the preclinical brain tumor models that are essential for translational development of these techniques. We also identify existing approved drugs that, if coupled with an efficient delivery method, could have potential as brain tumor treatments. Bringing this information together is part of a funded initiative to highlight drug delivery as a research strategy to overcome the current challenges for children diagnosed with brain tumors. | por |
dc.description.sponsorship | This review was written on behalf of the Children's Brain Tumor Drug Delivery Consortium, which is funded by Children with Cancer UK, grant number 16-244. This review was also supported by Maryland's Cancer Moonshot Initiative in Pediatric Cancer Research, grant number Project 4'. | por |
dc.language.iso | eng | por |
dc.publisher | MDPI | por |
dc.rights | openAccess | por |
dc.subject | Brain | por |
dc.subject | Drugs | por |
dc.subject | Tumour | por |
dc.subject | Drug delivery | por |
dc.subject | Blood–brain barrier | por |
dc.subject | Brain tumor model | por |
dc.subject | Preclinical | por |
dc.subject | Xenograft | por |
dc.subject | Companion animal | por |
dc.subject | Childhood brain tumors | por |
dc.subject | Drug repurposing | por |
dc.title | Childhood brain tumors: A review of strategies to translate CNS drug delivery to clinical trials | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/2072-6694/15/3/857 | por |
dc.comments | http://3bs.uminho.pt/node/20894 | por |
oaire.citationIssue | 3 | por |
oaire.citationVolume | 15 | por |
dc.date.updated | 2023-02-08T14:19:22Z | - |
dc.identifier.doi | 10.3390/cancers15030857 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Cancers | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20894-cancers-15-00857.pdf | 3,47 MB | Adobe PDF | Ver/Abrir |