Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/80985
Título: | Use of pressurized and airlift bioreactors for citric acid production by Yarrowia lipolytica from crude glycerol |
Autor(es): | Ferreira, Patrícia Lopes, Marlene Belo, Isabel |
Palavras-chave: | Yarrowia lipolytica Citric acid Crude glycerol Airlift bioreactor Pressurized bioreactor Oxygen mass transfer rate |
Data: | 30-Nov-2022 |
Editora: | MDPI |
Revista: | Fermentation |
Citação: | Ferreira, P.; Lopes, M.; Belo, I. Use of Pressurized and Airlift Bioreactors for Citric Acid Production by Yarrowia lipolytica from Crude Glycerol. Fermentation 2022, 8, 700. https://doi.org/10.3390/fermentation8120700 |
Resumo(s): | Citric acid production is generally carried out in an aqueous medium in stirred tank reactors (STR), where the solubility of oxygen is low and the oxygen demand of microbial cultures is high. Thus, for this bioprocess, providing adequate oxygen mass transfer rate (OTR) from the gas phase into the aqueous culture medium is the main challenge of bioreactor selection and operation. In this study, citric acid production by Yarrowia lipolytica W29 from crude glycerol, in batch cultures, was performed in two non-conventional bioreactors normally associated with high mass transfer efficiency: a pressurized STR and an airlift bioreactor. Increased OTR was obtained by raising the total air pressure in the pressurized STR and by increasing the aeration rate in the airlift bioreactor. An improvement of 40% in maximum citric acid titer was obtained by raising the air pressure from 1 bar to 2 bar, whereas, in the airlift bioreactor, a 30% improvement was attained by increasing the aeration rate from 1 vvm to 1.5 vvm. Both bioreactor types can be successfully applied for the citric acid production process using alternative ways of improving OTR than increasing mechanical stirring power input, thus leading to important operating saving costs. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/80985 |
DOI: | 10.3390/fermentation8120700 |
e-ISSN: | 2311-5637 |
Versão da editora: | https://www.mdpi.com/2311-5637/8/12/700 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_55920_1.pdf | 941,27 kB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons