Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/80471
Título: | Design of new hydrolyzed collagen-modified magnetic nanoparticles to capture pathogens |
Autor(es): | Sande, Maria Georgina Roque, Lúcia Braga, Adelaide Correia Marques, Márcia Ferreira, Débora Carina Gonçalves Abreu Saragliadis, Athanasios Rodrigues, Joana Lúcia Lima Correia Linke, Dirk Ramada, David Silva, C. Rodrigues, L. R. |
Palavras-chave: | Adhesins Arginine magnetic nanoparticles Bacterial adhesion Enrichment Hydrolyzed collagen magnetic nanoparticles Ubiquitous surface protein A2 (UspA2) Yersinia adhesin A (YadA) |
Data: | Fev-2023 |
Editora: | Wiley |
Revista: | Journal of Biomedical Materials Research - Part B: Applied Biomaterials |
Citação: | Sande, MG, Roque, L, Braga, A, et al. Design of new hydrolyzed collagen-modified magnetic nanoparticles to capture pathogens. J Biomed Mater Res. 2023; 111( 2): 354- 365. doi:10.1002/jbm.b.35155 |
Resumo(s): | Enrichment and diagnosis tools for pathogens currently available are time consuming, thus the development of fast and highly sensitive alternatives is desirable. In this study, a novel approach was described that enables selective capture of bacteria expressing hydrolyzed collagen-binding adhesins with hydrolyzed collagen-coated magnetic nanoparticles (MNPs). This platform could be useful to shorten the time needed to confirm the presence of a bacterial infection. MNPs were synthesized by a simple two-step approach through a green co-precipitation method using water as solvent. These MNPs were specifically designed to interact with pathogenic bacteria by establishing a hydrolyzed collagen-adhesin linker. The bacterial capture efficacy of hydrolyzed collagen MNPs (H-Coll |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/80471 |
DOI: | 10.1002/jbm.b.35155 |
ISSN: | 1552-4973 |
e-ISSN: | 1552-4981 |
Versão da editora: | https://onlinelibrary.wiley.com/doi/10.1002/jbm.b.35155 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
document_55749_1.pdf Acesso restrito! | 4,19 MB | Adobe PDF | Ver/Abrir |