Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/76434
Título: | Synergistic effects between metal nanoparticles and commercial antimicrobial agents: a review |
Autor(es): | Ribeiro, Ana Isabel Ferreira Dias, Alice Maria Zille, Andrea |
Palavras-chave: | Antimicrobial agents Metal nanoparticles Synergism Antivirus Antifungals Antibiotics |
Data: | 2022 |
Editora: | American Chemical Society (ACS) |
Revista: | ACS Applied Nano Materials |
Resumo(s): | Nanotechnology has expanded into a broad range of clinical applications. In particular, metal nanoparticles (MNPs) display unique antimicrobial properties, a fundamental function of novel medical devices. The combination of MNPs with commercial antimicrobial drugs (e.g., antibiotics, antifungals, and antivirals) may offer several opportunities to overcome some disadvantages of their individual use and enhance effectiveness. MNP conjugates display multiple advantages. As drug delivery systems, the conjugates can extend the circulation of the drugs in the body, facilitate intercellular targeting, improve drug stabilization, and possess superior delivery. Concomitantly, they reduce the required drug dose, minimize toxicity, and broaden the antimicrobial spectrum. In this work, the common strategies to combine MNPs with clinically used antimicrobial agents are underscored. Furthermore, a comprehensive survey about synergistic antimicrobial effects, the mechanism of action, and cytotoxicity is depicted. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/76434 |
DOI: | 10.1021/acsanm.1c03891 |
e-ISSN: | 2574-0970 |
Versão da editora: | https://pubs.acs.org/doi/10.1021/acsanm.1c03891 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDQuim - Artigos (Papers) DET/2C2T - Artigos em revistas internacionais com arbitragem científica |