Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/76434
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Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Ribeiro, Ana Isabel Ferreira | por |
dc.contributor.author | Dias, Alice Maria | por |
dc.contributor.author | Zille, Andrea | por |
dc.date.accessioned | 2022-03-08T09:10:45Z | - |
dc.date.available | 2022-03-08T09:10:45Z | - |
dc.date.issued | 2022 | - |
dc.identifier.uri | https://hdl.handle.net/1822/76434 | - |
dc.description.abstract | Nanotechnology has expanded into a broad range of clinical applications. In particular, metal nanoparticles (MNPs) display unique antimicrobial properties, a fundamental function of novel medical devices. The combination of MNPs with commercial antimicrobial drugs (e.g., antibiotics, antifungals, and antivirals) may offer several opportunities to overcome some disadvantages of their individual use and enhance effectiveness. MNP conjugates display multiple advantages. As drug delivery systems, the conjugates can extend the circulation of the drugs in the body, facilitate intercellular targeting, improve drug stabilization, and possess superior delivery. Concomitantly, they reduce the required drug dose, minimize toxicity, and broaden the antimicrobial spectrum. In this work, the common strategies to combine MNPs with clinically used antimicrobial agents are underscored. Furthermore, a comprehensive survey about synergistic antimicrobial effects, the mechanism of action, and cytotoxicity is depicted. | por |
dc.description.sponsorship | This work was funded by European Regional Development Fund through the Operational Competitiveness Program and through the National Foundation for Science and Technology of Portugal (FCT) under the projects UID/CTM/00264/2021 and MEDCOR PTDC/CTM TEX/1213/2020. A. Isabel Ribeiro acknowledges FCT, Portuguese Ministry of Science Technology and Higher Education, European Social Fund and European Union PhD grant SFRH/BD/137668/2018. | - |
dc.language.iso | eng | por |
dc.publisher | American Chemical Society (ACS) | por |
dc.relation | UID/CTM/00264/2021 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCTM-TEX%2F1213%2F2020/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F137668%2F2018/PT | por |
dc.rights | openAccess | por |
dc.subject | Antimicrobial agents | por |
dc.subject | Metal nanoparticles | por |
dc.subject | Synergism | por |
dc.subject | Antivirus | por |
dc.subject | Antifungals | por |
dc.subject | Antibiotics | por |
dc.title | Synergistic effects between metal nanoparticles and commercial antimicrobial agents: a review | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://pubs.acs.org/doi/10.1021/acsanm.1c03891 | por |
oaire.citationStartPage | 3030 | por |
oaire.citationEndPage | 3064 | por |
oaire.citationIssue | 3 | por |
oaire.citationVolume | 5 | por |
dc.identifier.eissn | 2574-0970 | por |
dc.identifier.doi | 10.1021/acsanm.1c03891 | por |
dc.subject.fos | Engenharia e Tecnologia::Engenharia dos Materiais | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | ACS Applied Nano Materials | por |
Aparece nas coleções: | CDQuim - Artigos (Papers) DET/2C2T - Artigos em revistas internacionais com arbitragem científica |