Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/74303
Título: | Silver(I) coordination polymers immobilized into biopolymer films for antimicrobial applications |
Autor(es): | Fernandes, Tiago A. Costa, Inês F. M. Jorge, Paula Alexandra Silva Sousa, Ana Catarina André, Vânia Cerca, Nuno Kirillov, Alexander M. |
Palavras-chave: | Metal-organic frameworks Silver Crystal structures Hybrid materials Antibacterial activity Biopolymers Biofilms |
Data: | 11-Mar-2021 |
Editora: | American Chemical Society |
Revista: | ACS Applied Materials & Interfaces |
Citação: | Fernandes, Tiago A.; Costa, Inês F. M.; Jorge, Paula; Sousa, Ana Catarina; André, Vânia; Cerca, Nuno; Kirillov, Alexander M., Silver(I) coordination polymers immobilized into biopolymer films for antimicrobial applications. ACS Applied Materials & Interfaces, 13(11), 12836-12844, 2021 |
Resumo(s): | This study describes a template-mediated self-assembly synthesis, full characterization, and structural features of two new silver-based bioactive coordination polymers (CPs) and their immobilization into acrylated epoxidized soybean oil (ESOA) biopolymer films for antimicrobial applications. The 3D silver(I) CPs [Ag4(?8-H2pma)2]n·4nH2O (1) and [Ag5(?6-H0.5tma)2(H2O)4]n·2nH2O (2) were generated from AgNO3 and pyromellitic (H4pma) or trimesic (H3tma) acid, also using N,N?-dimethylethanolamine (Hdmea) as a template. Both 1 and 2 feature the intricate 3D layer-pillared structures driven by distinct polycarboxylate blocks. Topological analysis revealed binodal nets with the flu and tcj/hc topology in 1 and 2, respectively. These CPs were used for fabricating new hybrid materials, namely, by doping the [ESOA]n biopolymer films with very low amounts of 1 and 2 (0.05, 0.1, and 0.5\%). Their antimicrobial activity and ability to impair bacterial biofilm formation were investigated in detail against both Gram-positive (Staphylococcus epidermidis and Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria. Both silver(I) CPs and derived biopolymer films showed activity against all the tested bacteria in a concentration-dependent manner. Compound 1 exhibited a more pronounced activity, especially in preventing biofilm growth, with mean bacterial load reductions ranging from 3.7 to 4.3 log against the four bacteria (99.99\% bacterial eradication). The present work thus opens up antibiofilm applications of CP-doped biopolymers, providing new perspectives and very promising results for the design of functional biomaterials. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/74303 |
DOI: | 10.1021/acsami.0c19446 |
ISSN: | 1944-8244 |
e-ISSN: | 1944-8252 |
Versão da editora: | http://pubs.acs.org/journal/aamick |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_54275_1.pdf Acesso restrito! | 3,37 MB | Adobe PDF | Ver/Abrir |