Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/72884
Título: | Ionic liquid-assisted synthesis of mesoporous silk fibroin/silica hybrids for biomedical applications |
Autor(es): | Pereira, Rui Francisco Gonçalves Pinto Fernandes Zehbe, Kerstin Guenter, Christina dos Santos, Tiago Nunes, Silvia C. Almeida Paz, Filipe A. Silva, Maria Manuela Granja, Pedro L. Taubert, Andreas Bermudez, Veroprimenica de Zea |
Data: | 2018 |
Editora: | American Chemical Society |
Revista: | ACS Omega |
Resumo(s): | New mesoporous silk fibroin (SF)/silica hybrids were processed via a one-pot soft and energy-efficient sol-gel chemistry and self-assembly from a silica precursor, an acidic or basic catalyst, and the ionic liquid 1-butyl-3-methylimidazolium chloride, acting as both solvent and mesoporosity-inducer. The as-prepared materials were obtained as slightly transparent-opaque, amorphous monoliths, easily transformed into powders, and stable up to ca. 300 degrees C. Structural data suggest the formation of a hexagonal mesostructure with low range order and apparent surface areas, pore volumes, and pore radii of 205-263 m(2) g(-1), 0.16-0.19 cm(3) g(-1), and 1.2-1.6 nm, respectively. In all samples, the dominating conformation of the SF chains is the beta-sheet. Cytotoxicity/bioactivity resazurin assays and fluorescence microscopy demonstrate the high viability of MC3T3 pre-osteoblasts to indirect (>= 99 +/- 9%) and direct (78 +/- 2 to 99 +/- 13%) contact with the SF/silica materials. Considering their properties and further improvements, these systems are promising candidates to be explored in bone tissue engineering. They also offer excellent prospects as electrolytes for solid-state electrochemical devices, in particular for fuel cells. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/72884 |
DOI: | 10.1021/acsomega.8b02051 |
ISSN: | 2470-1343 |
Versão da editora: | https://pubs.acs.org/doi/10.1021/acsomega.8b02051 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Silk-silica FAAP.pdf Acesso restrito! | 1,33 MB | Adobe PDF | Ver/Abrir |