Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/72884
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Pereira, Rui Francisco Gonçalves Pinto Fernandes | por |
dc.contributor.author | Zehbe, Kerstin | por |
dc.contributor.author | Guenter, Christina | por |
dc.contributor.author | dos Santos, Tiago | por |
dc.contributor.author | Nunes, Silvia C. | por |
dc.contributor.author | Almeida Paz, Filipe A. | por |
dc.contributor.author | Silva, Maria Manuela | por |
dc.contributor.author | Granja, Pedro L. | por |
dc.contributor.author | Taubert, Andreas | por |
dc.contributor.author | Bermudez, Veroprimenica de Zea | por |
dc.date.accessioned | 2021-05-27T09:25:29Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 2470-1343 | por |
dc.identifier.uri | https://hdl.handle.net/1822/72884 | - |
dc.description.abstract | New mesoporous silk fibroin (SF)/silica hybrids were processed via a one-pot soft and energy-efficient sol-gel chemistry and self-assembly from a silica precursor, an acidic or basic catalyst, and the ionic liquid 1-butyl-3-methylimidazolium chloride, acting as both solvent and mesoporosity-inducer. The as-prepared materials were obtained as slightly transparent-opaque, amorphous monoliths, easily transformed into powders, and stable up to ca. 300 degrees C. Structural data suggest the formation of a hexagonal mesostructure with low range order and apparent surface areas, pore volumes, and pore radii of 205-263 m(2) g(-1), 0.16-0.19 cm(3) g(-1), and 1.2-1.6 nm, respectively. In all samples, the dominating conformation of the SF chains is the beta-sheet. Cytotoxicity/bioactivity resazurin assays and fluorescence microscopy demonstrate the high viability of MC3T3 pre-osteoblasts to indirect (>= 99 +/- 9%) and direct (78 +/- 2 to 99 +/- 13%) contact with the SF/silica materials. Considering their properties and further improvements, these systems are promising candidates to be explored in bone tissue engineering. They also offer excellent prospects as electrolytes for solid-state electrochemical devices, in particular for fuel cells. | por |
dc.description.sponsorship | This work was supported by Fundacao para a Ciencia e a Tecnologia (FCT)/Deutscher Akademischer Austauschdienst (DAAD) Transnational Cooperation Project no. 6818 "Ionic liquid-and ionic liquid crystal-assisted formation of hybrid biomaterials scaffolds". We further wish to thank the European Union, QREN, FEDER through "Programa Operacional Factores de Competitividade" (COMPETE), and CICECO-Aveiro Institute of Materials, POCI-01-0145-FEDER-007679 (FCT Ref. UID/CTM/50011/2013), financed by national funds through the FCT/MEC and when appropriate co-financed by FEDER under the PT2020 Partnership Agreement. This work was also funded by project UniRCell (POCI-01-0145-FEDER-016422 and SAICTPAC/0032/2015) financed by the European Regional Development Fund (ERDF) through COMPETE 2020, POCI and FCT. We also thank FCT in the framework of Strategic Funding UID/QUI/00686/2013 and UID/QUI/00686/2016, and funding under project PEst-OE/QUI/UI0616/2014. R.F.P.P. acknowledges FCT for a grant (SFRH/BPD/87759/2012). | por |
dc.language.iso | eng | por |
dc.publisher | American Chemical Society | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147332/PT | por |
dc.relation | SAICTPAC/0032/2015 | por |
dc.relation | UID/QUI/00686/2013 | por |
dc.relation | UID/QUI/00686/2016 | por |
dc.relation | PEst-OE/QUI/UI0616/2014 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F87759%2F2012/PT | por |
dc.rights | restrictedAccess | por |
dc.title | Ionic liquid-assisted synthesis of mesoporous silk fibroin/silica hybrids for biomedical applications | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://pubs.acs.org/doi/10.1021/acsomega.8b02051 | por |
oaire.citationStartPage | 10811 | por |
oaire.citationEndPage | 10822 | por |
oaire.citationIssue | 9 | por |
oaire.citationVolume | 3 | por |
dc.date.updated | 2021-05-21T16:19:11Z | - |
dc.identifier.doi | 10.1021/acsomega.8b02051 | por |
dc.date.embargo | 10000-01-01 | - |
dc.subject.fos | Ciências Naturais::Ciências Químicas | por |
dc.subject.wos | Science & Technology | - |
sdum.export.identifier | 10784 | - |
sdum.journal | ACS Omega | por |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Silk-silica FAAP.pdf Acesso restrito! | 1,33 MB | Adobe PDF | Ver/Abrir |