Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/71525
Título: | Polymeric micelles using cholinium-based ionic liquids for the encapsulation and release of hydrophobic drug molecules |
Autor(es): | Kurnik, Isabelle S. D'Angelo, Natália A. Mazzola, Priscila G. Chorilli, Marlus Kamei, Daniel T. Pereira, Jorge F. B. Vicente, A. A. Lopes, André M. |
Palavras-chave: | Polymeric micelles cholinium-based ionic liquids encapsulation and release of hydrophobic drug molecules |
Data: | 2021 |
Editora: | Royal Society of Chemistry |
Revista: | Biomaterials Science |
Citação: | Kurnik, Isabelle S.; D'Angelo, Natália A.; Mazzola, Priscila G.; Chorilli, Marlus; Kamei, Daniel T.; Pereira, Jorge F. B.; Vicente, António A.; Lopes, André M., Polymeric micelles using cholinium-based ionic liquids for the encapsulation and release of hydrophobic drug molecules. Biomaterials Science, 9, 2183-2196, 2021 |
Resumo(s): | We generated stable amphiphilic copolymer-based polymeric micelles (PMs) with temperature-responsive properties utilizing Pluronic® L35 and a variety of ionic liquids (ILs) to generate different aqueous two-phase micellar systems (ATPMSs). The partitioning of the hydrophobic model compound curcumin (CCM) into the PM-rich phase and the drug delivery capabilities of the PMs were investigated. ATPMSs formed using more hydrophobic ILs (i.e., [Ch][Hex] [Ch][But] > [Ch][Pro] > [Ch][Ac] [Ch]Cl) were the most effective in partitioning (KCCM) and recovering (RECRich) CCM into the PM-rich phase (15.2 < KCCM < 22.0 and 90% < RECRich < 95%, respectively). Moreover, using 1.2 M [Ch][But] and 0.2 M [Ch][Hex] ILs yielded higher encapsulation efficiency (EE) (94.1 and 96.0%, respectively) and drug loading (DL) capacity (14.8 and 16.2%, respectively), together with an increase in the average hydrodynamic diameter of the PMs (DH) (42.5 and 45.6 nm, respectively). The CCMPM formulations were stable at 4.0, 25.0, and 37.0 °C and the release of CCM was faster with the less hydrophobic ILs (i.e., [Ch]Cl and [Ch][Ac]). Furthermore, due to the lower critical solution temperature properties of Pluronic® L35, the PMs exhibit temperature responsiveness at 37.0 °C. In vitro cytotoxicity assays were also performed to determine the potency of CCMPM formulations, and a 1.8-fold decrease in IC50 values was observed between the CCMPMs/[Ch][Hex] and CCMPMs/[Ch]Cl formulations for PC3 cells. The lower IC50 value for the [Ch][Hex] version corresponded to a greater potency compared to the [Ch]Cl version, since a lower concentration of CCM was required to achieve the same therapeutic effect. The ATPMSs investigated in this study serve as a novel platform for Pluronic® L35/PBS buffer (pH 7.4) + IL-based ATPMS development. The unique properties reported here may be useful in applications such as controlled-release drug delivery systems (DDS), encapsulation, and bioseparations. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/71525 |
DOI: | 10.1039/D0BM01884H |
ISSN: | 2047-4830 |
Versão da editora: | https://pubs.rsc.org/en/journals/journalissues/bm |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_54362_1.pdf Acesso restrito! | 2,4 MB | Adobe PDF | Ver/Abrir |