Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/71525
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Campo DC | Valor | Idioma |
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dc.contributor.author | Kurnik, Isabelle S. | por |
dc.contributor.author | D'Angelo, Natália A. | por |
dc.contributor.author | Mazzola, Priscila G. | por |
dc.contributor.author | Chorilli, Marlus | por |
dc.contributor.author | Kamei, Daniel T. | por |
dc.contributor.author | Pereira, Jorge F. B. | por |
dc.contributor.author | Vicente, A. A. | por |
dc.contributor.author | Lopes, André M. | por |
dc.date.accessioned | 2021-04-10T14:14:51Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Kurnik, Isabelle S.; D'Angelo, Natália A.; Mazzola, Priscila G.; Chorilli, Marlus; Kamei, Daniel T.; Pereira, Jorge F. B.; Vicente, António A.; Lopes, André M., Polymeric micelles using cholinium-based ionic liquids for the encapsulation and release of hydrophobic drug molecules. Biomaterials Science, 9, 2183-2196, 2021 | por |
dc.identifier.issn | 2047-4830 | por |
dc.identifier.uri | https://hdl.handle.net/1822/71525 | - |
dc.description.abstract | We generated stable amphiphilic copolymer-based polymeric micelles (PMs) with temperature-responsive properties utilizing Pluronic® L35 and a variety of ionic liquids (ILs) to generate different aqueous two-phase micellar systems (ATPMSs). The partitioning of the hydrophobic model compound curcumin (CCM) into the PM-rich phase and the drug delivery capabilities of the PMs were investigated. ATPMSs formed using more hydrophobic ILs (i.e., [Ch][Hex] [Ch][But] > [Ch][Pro] > [Ch][Ac] [Ch]Cl) were the most effective in partitioning (KCCM) and recovering (RECRich) CCM into the PM-rich phase (15.2 < KCCM < 22.0 and 90% < RECRich < 95%, respectively). Moreover, using 1.2 M [Ch][But] and 0.2 M [Ch][Hex] ILs yielded higher encapsulation efficiency (EE) (94.1 and 96.0%, respectively) and drug loading (DL) capacity (14.8 and 16.2%, respectively), together with an increase in the average hydrodynamic diameter of the PMs (DH) (42.5 and 45.6 nm, respectively). The CCMPM formulations were stable at 4.0, 25.0, and 37.0 °C and the release of CCM was faster with the less hydrophobic ILs (i.e., [Ch]Cl and [Ch][Ac]). Furthermore, due to the lower critical solution temperature properties of Pluronic® L35, the PMs exhibit temperature responsiveness at 37.0 °C. In vitro cytotoxicity assays were also performed to determine the potency of CCMPM formulations, and a 1.8-fold decrease in IC50 values was observed between the CCMPMs/[Ch][Hex] and CCMPMs/[Ch]Cl formulations for PC3 cells. The lower IC50 value for the [Ch][Hex] version corresponded to a greater potency compared to the [Ch]Cl version, since a lower concentration of CCM was required to achieve the same therapeutic effect. The ATPMSs investigated in this study serve as a novel platform for Pluronic® L35/PBS buffer (pH 7.4) + IL-based ATPMS development. The unique properties reported here may be useful in applications such as controlled-release drug delivery systems (DDS), encapsulation, and bioseparations. | por |
dc.description.sponsorship | This study was funded by the Coordination for Higher Level Graduate Improvements (CAPES/Brazil, finance code 001), the National Council for Scientific and Technological Development (CNPq/Brazil) and the State of São Paulo Research Foundation (FAPESP/Brazil, processes #2014/16424-7, #2017/10789-1, #2018/10799-0, #2018/05111-9, #2019/05624-9, #2019/08549-8, and #2020/03727-2). | por |
dc.language.iso | eng | por |
dc.publisher | Royal Society of Chemistry | por |
dc.rights | restrictedAccess | por |
dc.subject | Polymeric micelles | por |
dc.subject | cholinium-based ionic liquids | por |
dc.subject | encapsulation and release of hydrophobic drug molecules | por |
dc.title | Polymeric micelles using cholinium-based ionic liquids for the encapsulation and release of hydrophobic drug molecules | eng |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://pubs.rsc.org/en/journals/journalissues/bm | por |
dc.comments | CEB54362 | por |
oaire.citationStartPage | 2183 | por |
oaire.citationEndPage | 2196 | por |
oaire.citationIssue | 6 | por |
oaire.citationConferencePlace | United Kingdom | - |
oaire.citationVolume | 9 | por |
dc.date.updated | 2021-04-10T10:52:05Z | - |
dc.identifier.doi | 10.1039/D0BM01884H | por |
dc.date.embargo | 10000-01-01 | - |
dc.identifier.pmid | 33502392 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Biomaterials Science | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
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document_54362_1.pdf Acesso restrito! | 2,4 MB | Adobe PDF | Ver/Abrir |