Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/71048
Título: | A kinetic model of the central carbon metabolism for acrylic acid production in Escherichia coli |
Autor(es): | Oliveira, Alexandre Rafael Machado Rodrigues, Joana Lúcia Lima Correia Ferreira, Eugénio C. Rodrigues, L. R. Dias, Oscar |
Data: | 8-Mar-2021 |
Editora: | Public Library of Science |
Revista: | PLoS Computational Biology |
Citação: | Oliveira, Alexandre; Rodrigues, Joana L.; Ferreira, Eugénio C.; Rodrigues, Lígia R.; Dias, Oscar, A kinetic model of the central carbon metabolism for acrylic acid production in Escherichia coli. PLoS Computational Biology, 17(3), e1008704, 2021. DOI: 10.1371/journal.pcbi.1008704 |
Resumo(s): | Acrylic acid is an economically important chemical compound due to its high market value. Nevertheless, the majority of acrylic acid consumed worldwide its produced from petroleum derivatives by a purely chemical process, which is not only expensive, but it also contributes towards environment deterioration. Hence, justifying the current need for sustainable novel production methods that allow higher profit margins. Ideally, to minimise production cost, the pathway should consist in the direct bio-based production from microbial feedstocks, such as Escherichia coli, but the current yields achieved are still too low to compete with conventional method. In this work, even though the glycerol pathway presented higher yields, we identified the malonyl-CoA route, when using glucose as carbon source, as having the most potential for industrial-scale production, since it is cheaper to implement. Furthermore, we also identified potential optimisation targets for all the tested pathways, that can help the bio-based method to compete with the conventional process. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/71048 |
DOI: | 10.1371/journal.pcbi.1008704 |
ISSN: | 1553-734X |
Versão da editora: | http://journals.plos.org/ploscompbiol/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_54285_1.pdf | 2,72 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons