Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/70789
Título: | Regeneration of critical-sized defects, in a goat model, using a dextrin-based hydrogel associated with granular synthetic bone substitute |
Autor(es): | Pereira, Isabel Sofia Melo Pereira, José Eduardo Maltez, Luís Rodrigues, Alexandra Rodrigues, Catarina Oliveira, Manuela Silva, Dina M. Caseiro, Ana Rita Prada, Justina Maurício, Ana Colette Santos, José Domingos Gama, F. M. |
Palavras-chave: | Polysaccharide Injectable hydrogel Granular ceramics Bonelike® Bone regeneration Calvarial defect Bonelike (R) |
Data: | Fev-2021 |
Editora: | Oxford University Press |
Revista: | Regenerative Biomaterials |
Citação: | Pereira, Isabel; Pereira, José Eduardo; Maltez, Luís; Rodrigues, Alexandra; Rodrigues, Ana Catarina; Oliveira, Manuela; Silva, Dina M.; Caseiro, Ana Rita; Prada, Justina; Maurício, Ana Colette; Santos, José Domingos; Gama, F. M., Regeneration of critical-sized defects, in a goat model, using a dextrin-based hydrogel associated with granular synthetic bone substitute. Regenerative Biomaterials, 8(1), rbaa036, 2021 |
Resumo(s): | The development of injectable bone substitutes (IBS) have obtained great importance in the bone regeneration field, as a strategy to reach hardly accessible defects using minimally invasive techniques and able to fit to irregular topographies. In this scenario, the association of injectable hydrogels and bone graft granules is emerging as a well-established trend. Particularly, in situ forming hydrogels have arisen as a new IBS generation. An in situ forming and injectable dextrin-based hydrogel (HG) was developed, aiming to act as a carrier of granular bone substitutes and bioactive agents. In this work, the HG was associated to a granular bone substitute (Bonelike®) and implanted in goat critical-sized calvarial defects (14mm) for 3, 6 and 12weeks. The results showed that HG improved the handling properties of the Bonelike® granules and did not affect its osteoconductive features, neither impairing the bone regeneration process. Human multipotent mesenchymal stromal cells from the umbilical cord, extracellular matrix hydrolysates and the pro-angiogenic peptide LLKKK18 were also combined with the IBS. These bioactive agents did not enhance the new bone formation significantly under the conditions tested, according to micro-computed tomography and histological analysis. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/70789 |
DOI: | 10.1093/rb/rbaa036 |
ISSN: | 2056-3418 |
e-ISSN: | 2056-3426 |
Versão da editora: | https://academic.oup.com/rb |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_54028_1.pdf Acesso restrito! | 729,57 kB | Adobe PDF | Ver/Abrir |