Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/70789
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Campo DC | Valor | Idioma |
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dc.contributor.author | Pereira, Isabel Sofia Melo | por |
dc.contributor.author | Pereira, José Eduardo | por |
dc.contributor.author | Maltez, Luís | por |
dc.contributor.author | Rodrigues, Alexandra | por |
dc.contributor.author | Rodrigues, Catarina | por |
dc.contributor.author | Oliveira, Manuela | por |
dc.contributor.author | Silva, Dina M. | por |
dc.contributor.author | Caseiro, Ana Rita | por |
dc.contributor.author | Prada, Justina | por |
dc.contributor.author | Maurício, Ana Colette | por |
dc.contributor.author | Santos, José Domingos | por |
dc.contributor.author | Gama, F. M. | por |
dc.date.accessioned | 2021-03-15T13:20:11Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.citation | Pereira, Isabel; Pereira, José Eduardo; Maltez, Luís; Rodrigues, Alexandra; Rodrigues, Ana Catarina; Oliveira, Manuela; Silva, Dina M.; Caseiro, Ana Rita; Prada, Justina; Maurício, Ana Colette; Santos, José Domingos; Gama, F. M., Regeneration of critical-sized defects, in a goat model, using a dextrin-based hydrogel associated with granular synthetic bone substitute. Regenerative Biomaterials, 8(1), rbaa036, 2021 | por |
dc.identifier.issn | 2056-3418 | por |
dc.identifier.uri | https://hdl.handle.net/1822/70789 | - |
dc.description.abstract | The development of injectable bone substitutes (IBS) have obtained great importance in the bone regeneration field, as a strategy to reach hardly accessible defects using minimally invasive techniques and able to fit to irregular topographies. In this scenario, the association of injectable hydrogels and bone graft granules is emerging as a well-established trend. Particularly, in situ forming hydrogels have arisen as a new IBS generation. An in situ forming and injectable dextrin-based hydrogel (HG) was developed, aiming to act as a carrier of granular bone substitutes and bioactive agents. In this work, the HG was associated to a granular bone substitute (Bonelike®) and implanted in goat critical-sized calvarial defects (14mm) for 3, 6 and 12weeks. The results showed that HG improved the handling properties of the Bonelike® granules and did not affect its osteoconductive features, neither impairing the bone regeneration process. Human multipotent mesenchymal stromal cells from the umbilical cord, extracellular matrix hydrolysates and the pro-angiogenic peptide LLKKK18 were also combined with the IBS. These bioactive agents did not enhance the new bone formation significantly under the conditions tested, according to micro-computed tomography and histological analysis. | por |
dc.description.sponsorship | This work was funded by the project ‘DEXGELERATION – Advanced solutions for bone regeneration based on dextrin hydrogels’ (Norte-07-0202-FEDER-038853). It was also funded by FCT under the scope of the strategic funding of UID/BIO/04469/2013 and UID/BIM/04293/2013 units and COMPETE 2020 (POCI-01-0145-FEDER-006684), BioTecNorte operation (NORTE-01-0145-FEDER-000004) and NORTE-01-0145-FEDER-000012 funded by FEDER under the scope of Norte2020 - Programa Operacional Regional do Norte. Isabel Pereira and Ana Rita Caseiro were supported by the grants SFRH/BD90066/2012 and SFRH/BD/101174/2014, respectively, from FCT, Portugal. | por |
dc.language.iso | eng | por |
dc.publisher | Oxford University Press | por |
dc.relation | UID/BIO/04469/2013 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147342/PT | por |
dc.relation | COMPETE 2020 (POCI-01-0145-FEDER-006684) | por |
dc.relation | NORTE-01-0145-FEDER-000004 | por |
dc.relation | NORTE-01-0145-FEDER-000012 | por |
dc.relation | SFRH/BD90066/2012 | por |
dc.relation | SFRH/BD/101174/2014 | por |
dc.rights | restrictedAccess | por |
dc.subject | Polysaccharide | por |
dc.subject | Injectable hydrogel | por |
dc.subject | Granular ceramics | por |
dc.subject | Bonelike® | por |
dc.subject | Bone regeneration | por |
dc.subject | Calvarial defect | por |
dc.subject | Bonelike (R) | por |
dc.title | Regeneration of critical-sized defects, in a goat model, using a dextrin-based hydrogel associated with granular synthetic bone substitute | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://academic.oup.com/rb | por |
dc.comments | CEB54028 | por |
oaire.citationStartPage | rbaa036(1) | por |
oaire.citationEndPage | rbaa036(10) | por |
oaire.citationIssue | 1 | por |
oaire.citationVolume | 8 | por |
dc.date.updated | 2021-03-13T14:03:23Z | - |
dc.identifier.eissn | 2056-3426 | por |
dc.identifier.doi | 10.1093/rb/rbaa036 | por |
dc.date.embargo | 10000-01-01 | - |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Regenerative Biomaterials | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
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document_54028_1.pdf Acesso restrito! | 729,57 kB | Adobe PDF | Ver/Abrir |