Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/69202
Título: | Impact of citrate and lipid-functionalized magnetic nanoparticles in dehydropeptide supramolecular magnetogels: properties, design and drug release |
Autor(es): | Veloso, Sérgio R S Silva, Joana F G Hilliou, L. Moura, Cacilda Coutinho, Paulo J. G. Martins, J. A. R. Testa-Anta, Martín Salgueiriño, Verónica Correa-Duarte, Miguel A Ferreira, Paula M. T. Castanheira, Elisabete M. S. |
Palavras-chave: | magnetic nanoparticles magnetogels drug delivery magnetic gels drug release magnetic hyperthermia magnetic lipogels supramolecular hydrogels self-assembly nanoparticle functionalization |
Data: | 2021 |
Editora: | MDPI |
Revista: | Nanomaterials |
Citação: | Veloso, S.R.S.; Silva, J.F.G.; Hilliou, L.; Moura, C.; Coutinho, P.J.G.; Martins, J.A.; Testa-Anta, M.; Salgueiriño, V.; Correa-Duarte, M.A.; Ferreira, P.M.T.; Castanheira, E.M.S. Impact of Citrate and Lipid-Functionalized Magnetic Nanoparticles in Dehydropeptide Supramolecular Magnetogels: Properties, Design and Drug Release. Nanomaterials 2021, 11, 16. |
Resumo(s): | Currently, the nanoparticle functionalization effect on supramolecular peptide-based hydrogels remains undescribed, but is expected to affect the hydrogels' self-assembly and final magnetic gel properties. Herein, two different functionalized nanoparticles: citrate-stabilized (14.4 ± 2.6 nm) and lipid-coated (8.9 ± 2.1 nm) magnetic nanoparticles, were used for the formation of dehydropeptide-based supramolecular magnetogels consisting of the ultra-short hydrogelator Cbz-L-Met-Z-ΔPhe-OH, with an assessment of their effect over gel properties. The lipid-coated nanoparticles were distributed along the hydrogel fibers, while citrate-stabilized nanoparticles were aggregated upon gelation, which resulted into a heating efficiency improvement and decrease, respectively. Further, the lipid-coated nanoparticles did not affect drug encapsulation and displayed improved drug release reproducibility compared to citrate-stabilized nanoparticles, despite the latter attaining a stronger AMF-trigger. This report points out that adsorption of nanoparticles to hydrogel fibers, which display domains that improve or do not affect drug encapsulation, can be explored as a means to optimize the development of supramolecular magnetogels to advance theranostic applications. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/69202 |
DOI: | 10.3390/nano11010016 |
Versão da editora: | https://www.mdpi.com/2079-4991/11/1/16 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | PHYSICS OF QUANTUM MATERIALS AND BIONANOSTRUCTURES (2018 - ...) CDQuim - Artigos (Papers) IPC - Artigos em revistas científicas internacionais com arbitragem |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
nanomaterials-11-00016-v2.pdf | Main text | 3,8 MB | Adobe PDF | Ver/Abrir |
Supplementary Information_Magnetogel.pdf | Supplementary Information | 2,31 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons