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https://hdl.handle.net/1822/66098
Título: | New silver (thio)semicarbazide derivatives: synthesis, structural features, and antimicrobial activity |
Autor(es): | Fernandes, Tiago A. André, Vânia Arol, Aliaksandr França, Ângela Maria Oliveira Sousa Mikhalyonok, Sergei Cerca, Nuno Kirillov, Alexander M. |
Data: | 27-Mai-2020 |
Editora: | Royal Society of Chemistry |
Revista: | New Journal of Chemistry |
Citação: | Fernandes, Tiago A.; André, Vânia; Arol, Aliaksandr; França, Angela; Mikhalyonok, Sergei; Cerca, Nuno; Kirillov, Alexander M., New silver (thio)semicarbazide derivatives: synthesis, structural features, and antimicrobial activity. New Journal of Chemistry, 44, 10924-10932, 2020 |
Resumo(s): | Two novel semicarbazide [HL1, 1, 1-((4-nitrophenyl)(phenyl)methylene)semicarbazide] and thiosemicarbazide [HL2, 2, 1-((4-nitrophenyl)(phenyl)methylene)thiosemicarbazide] ligands were generated from 4-nitrobenzophenone and the corresponding (thio)semicarbazide precursors. Compounds 1 and 2 were fully characterized and their X-ray crystal structures were established. These organic derivatives were further applied as bioactive building blocks for the self-assembly synthesis of silver(i) coordination compounds. The reactions of silver(i) nitrate with HL1/HL2 in the presence of aqueous NH4OH resulted in new silver(i) coordination compounds formulated as [Ag(HL1)(NO3)]·H2O (3) and [Ag6(?3-L2)6] (4). These complexes were characterized by standard methods (FT-IR, NMR, ESI-MS, and elemental analysis) as well as single-crystal X-ray diffraction. The structure of 3 features a two-coordinate silver(i) center with a distorted linear AgNO geometry, wherein an unusual coordination of HL1 through the nitrogen atom of the amine group is realized. The structure of 4 reveals a discrete Ag6 cluster composed of two joined trisilver(i) rings, wherein the three-coordinate Ag(i) centers adopt an AgNS2 environment. The antimicrobial activity of 14 was screened against Gram-positive (S. epidermidis and S. aureus) and Gram-negative (P. aeruginosa and E. coli) bacteria. Compound 4 presented antimicrobial activity against Gram-positive bacteria, including the ability to impair biofilm formation. This study thus contributes to a still limited research area on the development of new silver coordination compounds with potential antibiofilm activity. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/66098 |
DOI: | 10.1039/D0NJ02013C |
ISSN: | 1144-0546 |
e-ISSN: | 1369-9261 |
Versão da editora: | https://pubs.rsc.org/en/content/articlehtml/2020/nj/d0nj02013c |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_53773_1.pdf Acesso restrito! | 2,54 MB | Adobe PDF | Ver/Abrir |