Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/66098
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Fernandes, Tiago A. | por |
dc.contributor.author | André, Vânia | por |
dc.contributor.author | Arol, Aliaksandr | por |
dc.contributor.author | França, Ângela Maria Oliveira Sousa | por |
dc.contributor.author | Mikhalyonok, Sergei | por |
dc.contributor.author | Cerca, Nuno | por |
dc.contributor.author | Kirillov, Alexander M. | por |
dc.date.accessioned | 2020-07-21T08:49:55Z | - |
dc.date.issued | 2020-05-27 | - |
dc.date.submitted | 2020-04 | - |
dc.identifier.citation | Fernandes, Tiago A.; André, Vânia; Arol, Aliaksandr; França, Angela; Mikhalyonok, Sergei; Cerca, Nuno; Kirillov, Alexander M., New silver (thio)semicarbazide derivatives: synthesis, structural features, and antimicrobial activity. New Journal of Chemistry, 44, 10924-10932, 2020 | por |
dc.identifier.issn | 1144-0546 | por |
dc.identifier.uri | https://hdl.handle.net/1822/66098 | - |
dc.description.abstract | Two novel semicarbazide [HL1, 1, 1-((4-nitrophenyl)(phenyl)methylene)semicarbazide] and thiosemicarbazide [HL2, 2, 1-((4-nitrophenyl)(phenyl)methylene)thiosemicarbazide] ligands were generated from 4-nitrobenzophenone and the corresponding (thio)semicarbazide precursors. Compounds 1 and 2 were fully characterized and their X-ray crystal structures were established. These organic derivatives were further applied as bioactive building blocks for the self-assembly synthesis of silver(i) coordination compounds. The reactions of silver(i) nitrate with HL1/HL2 in the presence of aqueous NH4OH resulted in new silver(i) coordination compounds formulated as [Ag(HL1)(NO3)]·H2O (3) and [Ag6(?3-L2)6] (4). These complexes were characterized by standard methods (FT-IR, NMR, ESI-MS, and elemental analysis) as well as single-crystal X-ray diffraction. The structure of 3 features a two-coordinate silver(i) center with a distorted linear AgNO geometry, wherein an unusual coordination of HL1 through the nitrogen atom of the amine group is realized. The structure of 4 reveals a discrete Ag6 cluster composed of two joined trisilver(i) rings, wherein the three-coordinate Ag(i) centers adopt an AgNS2 environment. The antimicrobial activity of 14 was screened against Gram-positive (S. epidermidis and S. aureus) and Gram-negative (P. aeruginosa and E. coli) bacteria. Compound 4 presented antimicrobial activity against Gram-positive bacteria, including the ability to impair biofilm formation. This study thus contributes to a still limited research area on the development of new silver coordination compounds with potential antibiofilm activity. | por |
dc.description.sponsorship | Fundação para a Ciência e Tecnologia (FCT) and Portugal 2020 (projects PTDC/QUI-QIN/29697/2017, LISBOA-01-0145-FEDER-029697, UIDB/00100/2020, UIDP/00100/2020, SFRH/BSAB/150368/2019 and REM2013). The publication was also prepared with the support of the RUDN University Program 5-100. TAF acknowledges the FCT for BPD grant SFRH/BPD/119980/2016 | por |
dc.language.iso | eng | por |
dc.publisher | Royal Society of Chemistry | por |
dc.relation | PTDC/QUI-QIN/29697/2017 | - |
dc.relation | UIDB/00100/2020 | - |
dc.relation | UIDP/00100/2020 | - |
dc.relation | SFRH/BSAB/150368/2019 | - |
dc.relation | SFRH/BPD/119980/2016 | - |
dc.rights | restrictedAccess | por |
dc.title | New silver (thio)semicarbazide derivatives: synthesis, structural features, and antimicrobial activity | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://pubs.rsc.org/en/content/articlehtml/2020/nj/d0nj02013c | por |
dc.comments | CEB53773 | por |
oaire.citationStartPage | 10924 | por |
oaire.citationEndPage | 10932 | por |
oaire.citationIssue | 26 | por |
oaire.citationVolume | 44 | por |
dc.date.updated | 2020-07-20T19:34:56Z | - |
dc.identifier.eissn | 1369-9261 | por |
dc.identifier.doi | 10.1039/D0NJ02013C | por |
dc.date.embargo | 10000-01-01 | - |
dc.subject.fos | Ciências Médicas::Biotecnologia Médica | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | New Journal of Chemistry | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
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document_53773_1.pdf Acesso restrito! | 2,54 MB | Adobe PDF | Ver/Abrir |