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https://hdl.handle.net/1822/5746
Título: | Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancer |
Autor(es): | Costa, Sandra Maria Araújo da Pinto, Daniela Pereira, Deolinda Vasconcelos, André Lopes, Carlos Afonso Osório, Teresa Lopes, Carlos Medeiros, Rui |
Palavras-chave: | XPD DNA repair NER Ovarian cancer Polymorphisms |
Data: | 2007 |
Editora: | Elsevier 1 |
Revista: | Cancer Letters |
Citação: | "Cancer letters". ISSN 0304-3835. (in Press). |
Resumo(s): | The purpose of this study was to evaluate the role of XPD genotypes as genetic indicator of susceptibility to ovarian cancer. We have used a case–control study. We analysed DNA samples from 141 ovarian cancer patients and 202 control subjects, for three XPD polymorphisms using PCR-RFLP. We observed that Asn312Asn XPD genotype carriers have increased susceptibility of ovarian cancer (ORZ2.46 95% CI 1.20–5.06; PZ0.015). Furthermore, we found that carriers of Gln751Gln XPD genotype have an increased susceptibility of ovarian cancer (ORZ3.40 95% CI 1.61–7.15; PZ0.001). Asn312Asn and Gln751Gln are particularly associated with an early-stage of disease. Our results suggest an important role for Asn312Asn and Gln751Gln XPD polymorphisms in the susceptibility to ovarian cancer. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/5746 |
DOI: | 10.1016/j.canlet.2006.03.014 |
ISSN: | 0304-3835 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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cl06_costas.pdf | 170,4 kB | Adobe PDF | Ver/Abrir |