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https://hdl.handle.net/1822/5746
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Campo DC | Valor | Idioma |
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dc.contributor.author | Costa, Sandra Maria Araújo da | - |
dc.contributor.author | Pinto, Daniela | - |
dc.contributor.author | Pereira, Deolinda | - |
dc.contributor.author | Vasconcelos, André | - |
dc.contributor.author | Lopes, Carlos Afonso | - |
dc.contributor.author | Osório, Teresa | - |
dc.contributor.author | Lopes, Carlos | - |
dc.contributor.author | Medeiros, Rui | - |
dc.date.accessioned | 2006-11-06T14:56:36Z | - |
dc.date.available | 2006-11-06T14:56:36Z | - |
dc.date.issued | 2007 | - |
dc.date.submitted | 2006-03-13 | - |
dc.identifier.citation | "Cancer letters". ISSN 0304-3835. (in Press). | eng |
dc.identifier.issn | 0304-3835 | eng |
dc.identifier.uri | https://hdl.handle.net/1822/5746 | - |
dc.description.abstract | The purpose of this study was to evaluate the role of XPD genotypes as genetic indicator of susceptibility to ovarian cancer. We have used a case–control study. We analysed DNA samples from 141 ovarian cancer patients and 202 control subjects, for three XPD polymorphisms using PCR-RFLP. We observed that Asn312Asn XPD genotype carriers have increased susceptibility of ovarian cancer (ORZ2.46 95% CI 1.20–5.06; PZ0.015). Furthermore, we found that carriers of Gln751Gln XPD genotype have an increased susceptibility of ovarian cancer (ORZ3.40 95% CI 1.61–7.15; PZ0.001). Asn312Asn and Gln751Gln are particularly associated with an early-stage of disease. Our results suggest an important role for Asn312Asn and Gln751Gln XPD polymorphisms in the susceptibility to ovarian cancer. | eng |
dc.language.iso | eng | eng |
dc.publisher | Elsevier 1 | eng |
dc.rights | openAccess | eng |
dc.subject | XPD | eng |
dc.subject | DNA repair | eng |
dc.subject | NER | eng |
dc.subject | Ovarian cancer | eng |
dc.subject | Polymorphisms | eng |
dc.title | Importance of xeroderma pigmentosum group D polymorphisms in susceptibility to ovarian cancer | eng |
dc.type | article | por |
dc.peerreviewed | yes | eng |
sdum.publicationstatus | published | eng |
oaire.citationStartPage | 324 | por |
oaire.citationEndPage | 330 | por |
oaire.citationIssue | 1-2 | por |
oaire.citationVolume | 246 | por |
dc.identifier.doi | 10.1016/j.canlet.2006.03.014 | por |
dc.identifier.pmid | 16677755 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Cancer Letters | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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cl06_costas.pdf | 170,4 kB | Adobe PDF | Ver/Abrir |