Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/56413
Título: | Tetracycline and rifampicin induced a viable but nonculturable state in Staphylococcus epidermidis biofilms |
Autor(es): | Carvalhais, Virgínia Maria Dinis Perez-Cabezas, B. Oliveira, Cátia Vitorino, R. Vilanova, Manuel Cerca, Nuno |
Palavras-chave: | antibiotics culturability dormancy Staphylococcus epidermidis biofilms viability viable but noncultivable cells |
Data: | 2018 |
Editora: | Future Medicine Ltd |
Revista: | Future Microbiology |
Citação: | Carvalhais, Virginia; Perez-Cabezas, B.; Oliveira C; Vitorino, R.; Vilanova, Manuel; Cerca, Nuno, Tetracycline and rifampicin induced a viable but nonculturable state in Staphylococcus epidermidis biofilms. Future Microbiology, 13(1), 27-36, 2018 |
Resumo(s): | AIM: The goal of this study was to determine the effectiveness of antibiotics on Staphylococcus epidermidis biofilms with different proportions of dormant bacteria, using clinical and commensal isolates. MATERIALS & METHODS: The ability of S. epidermidis isolates to develop a dormant state was determined. The susceptibility of biofilms with prevented or induced dormancy to antibiotics was evaluated by enumeration of viable and cultivable cells, and confocal microscopy. RESULTS: Dormancy was observed in the majority of tested strains. Tetracycline and rifampicin enhanced the development of a viable but noncultivable biofilm state. CONCLUSION: Biofilms with induced dormancy were more likely to survive rifampicin. Furthermore, we found that the reduction of cultivable cells was not sufficient to reach definite conclusions on antimicrobial effectiveness. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/56413 |
DOI: | 10.2217/fmb-2017-0107 |
ISSN: | 1746-0913 |
e-ISSN: | 1746-0921 |
Versão da editora: | http://www.futuremedicine.com/loi/fmb |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_47350_1.pdf Acesso restrito! | 2 MB | Adobe PDF | Ver/Abrir |