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https://hdl.handle.net/1822/56413
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Campo DC | Valor | Idioma |
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dc.contributor.author | Carvalhais, Virgínia Maria Dinis | por |
dc.contributor.author | Perez-Cabezas, B. | por |
dc.contributor.author | Oliveira, Cátia | por |
dc.contributor.author | Vitorino, R. | por |
dc.contributor.author | Vilanova, Manuel | por |
dc.contributor.author | Cerca, Nuno | por |
dc.date.accessioned | 2018-10-19T17:21:03Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Carvalhais, Virginia; Perez-Cabezas, B.; Oliveira C; Vitorino, R.; Vilanova, Manuel; Cerca, Nuno, Tetracycline and rifampicin induced a viable but nonculturable state in Staphylococcus epidermidis biofilms. Future Microbiology, 13(1), 27-36, 2018 | por |
dc.identifier.issn | 1746-0913 | por |
dc.identifier.uri | https://hdl.handle.net/1822/56413 | - |
dc.description.abstract | AIM: The goal of this study was to determine the effectiveness of antibiotics on Staphylococcus epidermidis biofilms with different proportions of dormant bacteria, using clinical and commensal isolates. MATERIALS & METHODS: The ability of S. epidermidis isolates to develop a dormant state was determined. The susceptibility of biofilms with prevented or induced dormancy to antibiotics was evaluated by enumeration of viable and cultivable cells, and confocal microscopy. RESULTS: Dormancy was observed in the majority of tested strains. Tetracycline and rifampicin enhanced the development of a viable but noncultivable biofilm state. CONCLUSION: Biofilms with induced dormancy were more likely to survive rifampicin. Furthermore, we found that the reduction of cultivable cells was not sufficient to reach definite conclusions on antimicrobial effectiveness. | por |
dc.description.sponsorship | This study was supported by FCT funding UID/BIO/04469/2013, UID/BIM/04501/2013 and UID/IC/00051/2013. V Carvalhais acknowledges the individual FCT Fellowship (SFRH/BD/78235/2011). Nuno Cerca is an Investigador FCT. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. | por |
dc.language.iso | eng | por |
dc.publisher | Future Medicine Ltd | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147337/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147343/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F78235%2F2011/PT | por |
dc.rights | restrictedAccess | por |
dc.subject | antibiotics | por |
dc.subject | culturability | por |
dc.subject | dormancy | por |
dc.subject | Staphylococcus epidermidis biofilms | por |
dc.subject | viability | por |
dc.subject | viable but noncultivable cells | por |
dc.title | Tetracycline and rifampicin induced a viable but nonculturable state in Staphylococcus epidermidis biofilms | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.futuremedicine.com/loi/fmb | por |
dc.comments | CEB47350 | por |
oaire.citationStartPage | 27 | por |
oaire.citationEndPage | 36 | por |
oaire.citationIssue | 1 | por |
oaire.citationConferencePlace | United Kingdom | - |
oaire.citationVolume | 13 | por |
dc.date.updated | 2018-10-19T15:49:50Z | - |
dc.identifier.eissn | 1746-0921 | por |
dc.identifier.doi | 10.2217/fmb-2017-0107 | por |
dc.identifier.pmid | 29227161 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Future Microbiology | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
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document_47350_1.pdf Acesso restrito! | 2 MB | Adobe PDF | Ver/Abrir |