Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/50324
Título: | Smart drug delivery systems for cancer therapy |
Autor(es): | Bárbara, Eduarda Ozolina, Raza Carvalho, Ana M. Soares, Telma Gonçalves, Hugo Jana B. Nieder, Jana B. Real Oliveira, M. Elisabete C.D. Lúcio, M. |
Data: | 4-Jul-2017 |
Resumo(s): | Ideal nanocarrier-based therapy, contains first a controlled mechanism for drug delivery, to minimize side effects in healthy tissues, and second has the ability to provide a controlled drug release to extend the therapeutic duration of the therapeutic treatment. Nanocarrier based chemotherapy is one of the few nanotechnology-based medical therapies that reached the clinics, already in 1995, when the commercial anti cancer drug delivery system DOXIL® was introduced in the market, but available systems are far from optimal selectivity and controlled release. Our work describes a combined spectroscopy and imaging study to evaluate the two aspects of a smart drug delivery system. In our study we used these DODAX:MO (1:2) formulations with a diameter of approx. 100 nm to study the biophysical characteristics when used for trafficking paclitaxel (PTX) and doxorubicin (DOX), both widely used chemotherapeutic anti-cancer drugs. Taking advantage of the of DOX intrinsic fluorescence also the cell uptake is studied for DODAB:MO (1:2) liposomal formulations. |
Tipo: | Comunicação em painel |
URI: | https://hdl.handle.net/1822/50324 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDF - FAMO - Comunicações/Communications (with refereeing) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Eduarda Bárbara et al.- RICI7-2017.pdf | 300,08 kB | Adobe PDF | Ver/Abrir |