Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/50324
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Bárbara, Eduarda | por |
dc.contributor.author | Ozolina, Raza | por |
dc.contributor.author | Carvalho, Ana M. | por |
dc.contributor.author | Soares, Telma | por |
dc.contributor.author | Gonçalves, Hugo | por |
dc.contributor.author | Jana B. Nieder, Jana B. | por |
dc.contributor.author | Real Oliveira, M. Elisabete C.D. | por |
dc.contributor.author | Lúcio, M. | por |
dc.date.accessioned | 2018-02-12T09:17:14Z | - |
dc.date.available | 2018-02-12T09:17:14Z | - |
dc.date.issued | 2017-07-04 | - |
dc.identifier.uri | https://hdl.handle.net/1822/50324 | - |
dc.description.abstract | Ideal nanocarrier-based therapy, contains first a controlled mechanism for drug delivery, to minimize side effects in healthy tissues, and second has the ability to provide a controlled drug release to extend the therapeutic duration of the therapeutic treatment. Nanocarrier based chemotherapy is one of the few nanotechnology-based medical therapies that reached the clinics, already in 1995, when the commercial anti cancer drug delivery system DOXIL® was introduced in the market, but available systems are far from optimal selectivity and controlled release. Our work describes a combined spectroscopy and imaging study to evaluate the two aspects of a smart drug delivery system. In our study we used these DODAX:MO (1:2) formulations with a diameter of approx. 100 nm to study the biophysical characteristics when used for trafficking paclitaxel (PTX) and doxorubicin (DOX), both widely used chemotherapeutic anti-cancer drugs. Taking advantage of the of DOX intrinsic fluorescence also the cell uptake is studied for DODAB:MO (1:2) liposomal formulations. | por |
dc.language.iso | eng | por |
dc.rights | openAccess | por |
dc.title | Smart drug delivery systems for cancer therapy | por |
dc.type | panelPresentation | por |
dc.peerreviewed | yes | por |
sdum.event.type | meeting | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
sdum.conferencePublication | VII Iberian Meeting on Colloids and Interfaces, 2017, July 4th - 7th , Madrid. | por |
Aparece nas coleções: | CDF - FAMO - Comunicações/Communications (with refereeing) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Eduarda Bárbara et al.- RICI7-2017.pdf | 300,08 kB | Adobe PDF | Ver/Abrir |