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https://hdl.handle.net/1822/50235
Título: | Role of P-selectin in thromboembolic events in patients with cancer |
Autor(es): | Fernandes, Lúcio Flávio Barbour Fregnani, José Humberto T.G. Strunz, Célia Maria Cássaro Nogueira, Adriana de Andrade Ramos Longatto, Adhemar |
Palavras-chave: | P-selectin thromboembolism D-dimer thrombosis |
Data: | 2-Jan-2018 |
Editora: | Spandidos Publications |
Revista: | Molecular and Clinical Oncology |
Citação: | Barbour Fernandes, L. F., Fregnani, J. H. T., Strunz, C. M. C., Nogueira, A. D. A. R., & Longatto‑Filho, A. (2018). Role of P‑selectin in thromboembolic events in patients with cancer. Molecular and Clinical Oncology, 8(1), 188-196 |
Resumo(s): | The objective of the present study was to evaluate the role of P-selectin in patients with cancer with suspected thromboembolic events (TEEs). Patients with cancer have a four times greater risk of developing TEEs. P-selectin is a glycoprotein that has the function of facilitating the interaction (adhesion) of leukocytes with the endothelium, or with platelets. There is a well-defined relationship between P-selectin and thrombosis; however, it is likely that the cut-off value of P-selectin for patients with cancer should be considered differently from that of the general population. In the present report, a prospective cross-sectional study was performed with patients of the Cancer Hospital of Barretos who were suspected of having TEEs. Among the 178 study participants, 167 (93.82%) were suspected of having deep vein thrombosis, while 59 of them (35.33%) were confirmed as such; and 11 (6.18%) were suspected of having pulmonary thromboembolism, while 3 of them were confirmed as such (27.69%). The mean results obtained were: P-selectin, 25.37 ng/ml; and D-dimer, 2,181.22 ng/ml. The P-selectin levels averaged 33.60 ng/ml with the confirmed TEE group compared with 20.40 ng/ml with the unconfirmed TEE group, with a standard deviation of 23.35 compared with 6.92 (P<0.001); and the level of D-dimer was 4,615.38 ng/ml compared with 977.52 ng/ml, with a standard deviation of 6,460.54 compared with 2,145.50 (P<0.001). Multiple logistic regression adjusted for distant metastases and the Eastern Cooperative Oncology Group (ECOG) score (2,3 and 4) were constructed. The cut-off value of P-selectin for patients with cancer was identified to be different from that reported in the literature for the general population, and the models using D-dimer and P-selectin therefore have been demonstrated to be a potentially useful tool to be used in a panel of tests to predict TEEs, either independently or in a prediction score. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/50235 |
DOI: | 10.3892/mco.2017.1482 |
ISSN: | 2049-9450 |
e-ISSN: | 2049-9469 |
Versão da editora: | https://www.spandidos-publications.com/mco/8/1/188 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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mco_8_1_188_pdf.pdf | 275,74 kB | Adobe PDF | Ver/Abrir |