Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/50235
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Campo DC | Valor | Idioma |
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dc.contributor.author | Fernandes, Lúcio Flávio Barbour | por |
dc.contributor.author | Fregnani, José Humberto T.G. | por |
dc.contributor.author | Strunz, Célia Maria Cássaro | por |
dc.contributor.author | Nogueira, Adriana de Andrade Ramos | por |
dc.contributor.author | Longatto, Adhemar | por |
dc.date.accessioned | 2018-02-08T17:34:09Z | - |
dc.date.issued | 2018-01-02 | - |
dc.identifier.citation | Barbour Fernandes, L. F., Fregnani, J. H. T., Strunz, C. M. C., Nogueira, A. D. A. R., & Longatto‑Filho, A. (2018). Role of P‑selectin in thromboembolic events in patients with cancer. Molecular and Clinical Oncology, 8(1), 188-196 | por |
dc.identifier.issn | 2049-9450 | - |
dc.identifier.uri | https://hdl.handle.net/1822/50235 | - |
dc.description.abstract | The objective of the present study was to evaluate the role of P-selectin in patients with cancer with suspected thromboembolic events (TEEs). Patients with cancer have a four times greater risk of developing TEEs. P-selectin is a glycoprotein that has the function of facilitating the interaction (adhesion) of leukocytes with the endothelium, or with platelets. There is a well-defined relationship between P-selectin and thrombosis; however, it is likely that the cut-off value of P-selectin for patients with cancer should be considered differently from that of the general population. In the present report, a prospective cross-sectional study was performed with patients of the Cancer Hospital of Barretos who were suspected of having TEEs. Among the 178 study participants, 167 (93.82%) were suspected of having deep vein thrombosis, while 59 of them (35.33%) were confirmed as such; and 11 (6.18%) were suspected of having pulmonary thromboembolism, while 3 of them were confirmed as such (27.69%). The mean results obtained were: P-selectin, 25.37 ng/ml; and D-dimer, 2,181.22 ng/ml. The P-selectin levels averaged 33.60 ng/ml with the confirmed TEE group compared with 20.40 ng/ml with the unconfirmed TEE group, with a standard deviation of 23.35 compared with 6.92 (P<0.001); and the level of D-dimer was 4,615.38 ng/ml compared with 977.52 ng/ml, with a standard deviation of 6,460.54 compared with 2,145.50 (P<0.001). Multiple logistic regression adjusted for distant metastases and the Eastern Cooperative Oncology Group (ECOG) score (2,3 and 4) were constructed. The cut-off value of P-selectin for patients with cancer was identified to be different from that reported in the literature for the general population, and the models using D-dimer and P-selectin therefore have been demonstrated to be a potentially useful tool to be used in a panel of tests to predict TEEs, either independently or in a prediction score. | por |
dc.language.iso | eng | por |
dc.publisher | Spandidos Publications | por |
dc.rights | openAccess | - |
dc.subject | P-selectin | por |
dc.subject | thromboembolism | por |
dc.subject | D-dimer | por |
dc.subject | thrombosis | por |
dc.title | Role of P-selectin in thromboembolic events in patients with cancer | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.spandidos-publications.com/mco/8/1/188 | por |
oaire.citationStartPage | 188 | por |
oaire.citationEndPage | 196 | por |
oaire.citationIssue | 1 | por |
oaire.citationVolume | 8 | por |
dc.date.updated | 2018-01-16T11:45:28Z | - |
dc.identifier.eissn | 2049-9469 | - |
dc.identifier.doi | 10.3892/mco.2017.1482 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Molecular and Clinical Oncology | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
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mco_8_1_188_pdf.pdf | 275,74 kB | Adobe PDF | Ver/Abrir |