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https://hdl.handle.net/1822/49017
Título: | High systemic IL-6 is associated with worse prognosis in patients with non-small cell lung cancer |
Autor(es): | Silva, Estela Maria Mariano, Vânia Sammartino Pastrez, Paula Roberta Aguiar Pinto, Miguel Cordoba Castro, António G. Syrjanen, Kari Juhani Longatto Filho, Adhemar |
Data: | 5-Jul-2017 |
Editora: | Public Library of Science (PLOS) |
Revista: | PLoS ONE |
Citação: | Silva, E. M., Mariano, V. S., Pastrez, P. R. A., Pinto, M. C., Castro, A. G., Syrjanen, K. J., & Longatto-Filho, A. (2017). High systemic IL-6 is associated with worse prognosis in patients with non-small cell lung cancer. PloS one, 12(7), e0181125 |
Resumo(s): | Characteristic cytokine patterns have been described in different cancer patients and they are related to their diagnosis, prognosis, prediction of treatment responses and survival. A panel of cytokines was evaluated in the plasma of non-small cell lung cancer (NSCLC) patients and healthy controls to investigate their profile and relationship with clinical characteristics and overall survival. The case-controlled cross-sectional study design recruited 77 patients with confirmed diagnosis of NSCLC (cases) and 91 healthy subjects (controls) aimed to examine peripheral pro-inflammatory and anti-inflammatory cytokines (IL-2, IL-4, IL-6, IL-10, IL-17A, TNF and IFN-gamma) by Cytometry Beads Arrays (CBA Flex) in. The cytokine IL-6 showed a statistically significant difference among groups with increased expression in the case group (p < 0.001). The correlation between the cytokines expression with patient's clinical characteristics variables revealed the cytokine IL-6 was found to be associated with gender, showing higher levels in male (p = 0.036), whereas IL-17A levels were associated with TNM stage, being higher in III-IV stages (p = 0.044). We observed worse overall survival for individuals with high levels of IL-6 when compared to those with low levels of this cytokine in 6, 12 and 24 months. Further studies of IL-6 levels in independent cohort could clarify the real role of IL-6 as an independent marker of prognostic of NSCLC. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/49017 |
DOI: | 10.1371/journal.pone.0181125 |
ISSN: | 1932-6203 |
e-ISSN: | 1932-6203 |
Versão da editora: | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181125 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |