Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/49017
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Silva, Estela Maria | por |
dc.contributor.author | Mariano, Vânia Sammartino | por |
dc.contributor.author | Pastrez, Paula Roberta Aguiar | por |
dc.contributor.author | Pinto, Miguel Cordoba | por |
dc.contributor.author | Castro, António G. | por |
dc.contributor.author | Syrjanen, Kari Juhani | por |
dc.contributor.author | Longatto Filho, Adhemar | por |
dc.date.accessioned | 2018-01-04T17:28:13Z | - |
dc.date.available | 2018-01-04T17:28:13Z | - |
dc.date.issued | 2017-07-05 | - |
dc.identifier.citation | Silva, E. M., Mariano, V. S., Pastrez, P. R. A., Pinto, M. C., Castro, A. G., Syrjanen, K. J., & Longatto-Filho, A. (2017). High systemic IL-6 is associated with worse prognosis in patients with non-small cell lung cancer. PloS one, 12(7), e0181125 | por |
dc.identifier.issn | 1932-6203 | por |
dc.identifier.uri | https://hdl.handle.net/1822/49017 | - |
dc.description.abstract | Characteristic cytokine patterns have been described in different cancer patients and they are related to their diagnosis, prognosis, prediction of treatment responses and survival. A panel of cytokines was evaluated in the plasma of non-small cell lung cancer (NSCLC) patients and healthy controls to investigate their profile and relationship with clinical characteristics and overall survival. The case-controlled cross-sectional study design recruited 77 patients with confirmed diagnosis of NSCLC (cases) and 91 healthy subjects (controls) aimed to examine peripheral pro-inflammatory and anti-inflammatory cytokines (IL-2, IL-4, IL-6, IL-10, IL-17A, TNF and IFN-gamma) by Cytometry Beads Arrays (CBA Flex) in. The cytokine IL-6 showed a statistically significant difference among groups with increased expression in the case group (p < 0.001). The correlation between the cytokines expression with patient's clinical characteristics variables revealed the cytokine IL-6 was found to be associated with gender, showing higher levels in male (p = 0.036), whereas IL-17A levels were associated with TNM stage, being higher in III-IV stages (p = 0.044). We observed worse overall survival for individuals with high levels of IL-6 when compared to those with low levels of this cytokine in 6, 12 and 24 months. Further studies of IL-6 levels in independent cohort could clarify the real role of IL-6 as an independent marker of prognostic of NSCLC. | por |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tencnológico (CNPq) [Grant number 401775/2012-7 to ALF]; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) [Grant number 2014/ 23414-8 to EMS] | por |
dc.language.iso | eng | por |
dc.publisher | Public Library of Science (PLOS) | por |
dc.rights | openAccess | por |
dc.title | High systemic IL-6 is associated with worse prognosis in patients with non-small cell lung cancer | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181125 | por |
oaire.citationIssue | 7 | por |
oaire.citationVolume | 12 | por |
dc.date.updated | 2017-12-19T11:07:24Z | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.doi | 10.1371/journal.pone.0181125 | por |
dc.identifier.pmid | 28715437 | por |
dc.subject.fos | Ciências Médicas::Medicina Básica | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | PLoS ONE | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |