Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/48493
Título: | The influence of copolymer composition on PLGA/nHA scaffolds´ cytotoxicity and in vitro degradation |
Autor(es): | Díaz, E. Puerto, I. Ribeiro, Sylvie Oliveira Lanceros-Méndez, S. Barandiarán, J. M. |
Palavras-chave: | Scaffolds PLGA nHA Cytotoxicity In vitro degradation |
Data: | Jul-2017 |
Editora: | MDPI |
Revista: | Nanomaterials |
Citação: | Díaz, E., Puerto, I., Ribeiro, S., Lanceros-Mendez, S., & Barandiarán, J. M. (2017). The Influence of Copolymer Composition on PLGA/nHA Scaffolds’ Cytotoxicity and In Vitro Degradation. Nanomaterials, 7(7), 173 |
Resumo(s): | The influence of copolymer composition on Poly(Lactide-co-Glycolide)/ nanohydroxyapatite (PLGA/nHA) composite scaffolds is studied in the context of bone tissue engineering and regenerative medicine. The composite scaffolds are fabricated by thermally-induced phase separation and the effect of bioactive nanoparticles on their in vitro degradation in phosphate-buffered solution at 37 °C is analyzed over eight weeks. The indirect cytotoxicity evaluation of the samples followed an adaptation of the ISO 10993-5 standard test method. Based on the measurement of their molecular weight, molar mass, pH, water absorption and dimensions, the porous scaffolds of PLGA with a lower lactide/glycolide (LA/GA) molar ratio degraded faster due to their higher hydrophilicity. All of the samples without and with HA are not cytotoxic, demonstrating their potential for tissue engineering applications. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/48493 |
DOI: | 10.3390/nano7070173 |
ISSN: | 2079-4991 |
e-ISSN: | 2079-4991 |
Versão da editora: | http://www.mdpi.com/2079-4991/7/7/173/htm |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDF - FCD - Artigos/Papers (with refereeing) |