Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/48493Registo completo
| Campo DC | Valor | Idioma |
|---|---|---|
| dc.contributor.author | Díaz, E. | por |
| dc.contributor.author | Puerto, I. | por |
| dc.contributor.author | Ribeiro, Sylvie Oliveira | por |
| dc.contributor.author | Lanceros-Méndez, S. | por |
| dc.contributor.author | Barandiarán, J. M. | por |
| dc.date.accessioned | 2017-12-21T11:49:55Z | - |
| dc.date.issued | 2017-07 | - |
| dc.date.submitted | 2017-05 | - |
| dc.identifier.citation | Díaz, E., Puerto, I., Ribeiro, S., Lanceros-Mendez, S., & Barandiarán, J. M. (2017). The Influence of Copolymer Composition on PLGA/nHA Scaffolds’ Cytotoxicity and In Vitro Degradation. Nanomaterials, 7(7), 173 | por |
| dc.identifier.issn | 2079-4991 | por |
| dc.identifier.uri | https://hdl.handle.net/1822/48493 | - |
| dc.description.abstract | The influence of copolymer composition on Poly(Lactide-co-Glycolide)/ nanohydroxyapatite (PLGA/nHA) composite scaffolds is studied in the context of bone tissue engineering and regenerative medicine. The composite scaffolds are fabricated by thermally-induced phase separation and the effect of bioactive nanoparticles on their in vitro degradation in phosphate-buffered solution at 37 °C is analyzed over eight weeks. The indirect cytotoxicity evaluation of the samples followed an adaptation of the ISO 10993-5 standard test method. Based on the measurement of their molecular weight, molar mass, pH, water absorption and dimensions, the porous scaffolds of PLGA with a lower lactide/glycolide (LA/GA) molar ratio degraded faster due to their higher hydrophilicity. All of the samples without and with HA are not cytotoxic, demonstrating their potential for tissue engineering applications. | por |
| dc.description.sponsorship | SGIker (UPV/EHU, MICINN, GV/EJ, ERDF and ESF) is really appreciated. This work was supported by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding UID/FIS/04650/2013 and Grant SFRH/BD/111478/2015 (S.R). The authors acknowledge funding by the Spanish Ministry of Economy and Competitiveness (MINECO) through the project MAT2016-76039-C4-3-R (Agencia Estatal de Investigación(AEI)/FEDER, Unión Europea(UE)) | por |
| dc.language.iso | eng | por |
| dc.publisher | MDPI | por |
| dc.relation | info:eu-repo/grantAgreement/FCT/5876/147414/PT | por |
| dc.rights | openAccess | por |
| dc.subject | Scaffolds | por |
| dc.subject | PLGA | por |
| dc.subject | nHA | por |
| dc.subject | Cytotoxicity | por |
| dc.subject | In vitro degradation | por |
| dc.title | The influence of copolymer composition on PLGA/nHA scaffolds´ cytotoxicity and in vitro degradation | por |
| dc.type | article | por |
| dc.peerreviewed | yes | por |
| dc.relation.publisherversion | http://www.mdpi.com/2079-4991/7/7/173/htm | por |
| oaire.citationIssue | 7 | por |
| oaire.citationVolume | 7 | por |
| dc.identifier.eissn | 2079-4991 | por |
| dc.identifier.doi | 10.3390/nano7070173 | por |
| dc.subject.fos | Ciências Naturais::Ciências Físicas | por |
| dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
| dc.subject.wos | Science & Technology | por |
| sdum.journal | Nanomaterials | por |
| Aparece nas coleções: | CDF - FCD - Artigos/Papers (with refereeing) | |
