Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/47808
Título: | Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation |
Autor(es): | Jennifer Noro Loureiro, Ana Isabel Sá Gonçalves, Filipa D. Azóia, Nuno G. Jung, Seunho Silva, Carla Cavaco-Paulo, Artur |
Palavras-chave: | Cyclo-oligosaccharides cyclosophoraose palmitoyl chloride phase-change nanoemulsions ultrasound |
Data: | Nov-2017 |
Editora: | Elsevier 1 |
Revista: | Colloids and Surfaces B: Biointerfaces |
Citação: | Jennifer Noro; Loureiro, Ana; Gonçalves, Filipa D.; Azoia, Nuno G.; Jung, Seunho; Silva, Carla; Cavaco-Paulo, Artur, Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation. Colloids and Surfaces B: Biointerfaces, 159, 259-267, 2017 |
Resumo(s): | New encapsulation nanodevices were synthesized by emulsification of cyclo-oligosaccharides fully substituted by hydrophobic palmitic chains. These highly hydrophobic compounds, acquire oily-like behaviour at moderate temperatures (50 °C) and when submitted to ultrasounds (US) can undergo emulsification. The improved emulsifying properties of modified cyclo-oligosaccharides are suitable to produce small and narrow sized nanoemulsions with ability to encapsulate amphiphilic molecules. Both encapsulation and delivery of a therapeutic drug, methotrexate (MTX), with amphiphilic character was assessed. The physicochemical properties of the cyclo-oligosaccharide nanoemulsions containing MTX were investigated by nuclear magnetic resonance (NMR), scanning transmission electron microscopy (STEM) and dynamic light scattering (DLS). The results revealed that the modified cyclo-oligosaccharides are potential platforms for the encapsulation of bio compounds for cosmetic and pharmaceutical purposes. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/47808 |
DOI: | 10.1016/j.colsurfb.2017.07.055 |
ISSN: | 09277765 |
e-ISSN: | 0927-7765 |
Versão da editora: | http://www.journals.elsevier.com/colloids-and-surfaces-b-biointerfaces/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_46889_1.pdf | 1,64 MB | Adobe PDF | Ver/Abrir |