Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/47808
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Jennifer Noro | por |
dc.contributor.author | Loureiro, Ana Isabel Sá | por |
dc.contributor.author | Gonçalves, Filipa D. | por |
dc.contributor.author | Azóia, Nuno G. | por |
dc.contributor.author | Jung, Seunho | por |
dc.contributor.author | Silva, Carla | por |
dc.contributor.author | Cavaco-Paulo, Artur | por |
dc.date.accessioned | 2017-11-27T21:24:31Z | - |
dc.date.available | 2017-11-27T21:24:31Z | - |
dc.date.issued | 2017-11 | - |
dc.identifier.citation | Jennifer Noro; Loureiro, Ana; Gonçalves, Filipa D.; Azoia, Nuno G.; Jung, Seunho; Silva, Carla; Cavaco-Paulo, Artur, Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation. Colloids and Surfaces B: Biointerfaces, 159, 259-267, 2017 | por |
dc.identifier.issn | 09277765 | por |
dc.identifier.uri | https://hdl.handle.net/1822/47808 | - |
dc.description.abstract | New encapsulation nanodevices were synthesized by emulsification of cyclo-oligosaccharides fully substituted by hydrophobic palmitic chains. These highly hydrophobic compounds, acquire oily-like behaviour at moderate temperatures (50 °C) and when submitted to ultrasounds (US) can undergo emulsification. The improved emulsifying properties of modified cyclo-oligosaccharides are suitable to produce small and narrow sized nanoemulsions with ability to encapsulate amphiphilic molecules. Both encapsulation and delivery of a therapeutic drug, methotrexate (MTX), with amphiphilic character was assessed. The physicochemical properties of the cyclo-oligosaccharide nanoemulsions containing MTX were investigated by nuclear magnetic resonance (NMR), scanning transmission electron microscopy (STEM) and dynamic light scattering (DLS). The results revealed that the modified cyclo-oligosaccharides are potential platforms for the encapsulation of bio compounds for cosmetic and pharmaceutical purposes. | por |
dc.description.sponsorship | ERDF -European Regional Development Fund | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.rights | openAccess | por |
dc.subject | Cyclo-oligosaccharides | por |
dc.subject | cyclosophoraose | por |
dc.subject | palmitoyl chloride | por |
dc.subject | phase-change | por |
dc.subject | nanoemulsions | por |
dc.subject | ultrasound | por |
dc.title | Oil-based cyclo-oligosaccharide nanodevices for drug encapsulation | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.journals.elsevier.com/colloids-and-surfaces-b-biointerfaces/ | por |
dc.comments | CEB46889 | por |
oaire.citationStartPage | 259 | por |
oaire.citationEndPage | 267 | por |
oaire.citationConferencePlace | Netherlands | - |
oaire.citationVolume | 159 | por |
dc.date.updated | 2017-08-16T11:59:54Z | - |
dc.identifier.eissn | 0927-7765 | por |
dc.identifier.doi | 10.1016/j.colsurfb.2017.07.055 | por |
dc.identifier.pmid | 28800465 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Colloids and Surfaces B: Biointerfaces | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_46889_1.pdf | 1,64 MB | Adobe PDF | Ver/Abrir |