Portrait of gene expression in C. glabrata with stress induced by drugs

Abstract

Candidiasis have globally increased over the last years, being a major cause of morbidity and mortality, especially in immunosuppressed and hospitalized patients. Candida albicans remains to be the most common species responsible in candidiasis, but Candida glabrata has appeared as second most common Candida in the USA and the third in Europe. Biofilms of this species are extremely difficult to eradicate and are a source of many recalcitrant infections. The goal of this study was to evaluate how C. glabrata cells try to adjust their biofilm composition in response to an antifungal drug treatment based on a series of profiles of eight genes expression - BGL2, FKS1, FKS2, GAS2, KHN1, UPG1, XOG1 and MNN2 known to be related to the production of -1,3, -1,6-glucans and mannans.