Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/46276
Título: | Exploring NAD(+) metabolism in host-pathogen interactions |
Autor(es): | Belinha, Ana Gaifem, Joana Mesquita, Inês Morais Silvestre, Ricardo Jorge Leal |
Palavras-chave: | Nicotinamide adenine dinucleotide (NAD?) Host-pathogen interaction NAD?/NADH ratio NADPH S Sirtuins L-tryptophan NADPH |
Data: | 2016 |
Editora: | Springer |
Revista: | Cellular and Molecular Life Sciences |
Resumo(s): | Nicotinamide adenine dinucleotide (NAD+) is a vital molecule found in all living cells. NAD+ intracellular levels are dictated by its synthesis, using the de novo and/or salvage pathway, and through its catabolic use as co-enzyme or co-substrate. The regulation of NAD+ metabolism has proven to be an adequate drug target for several diseases, including cancer, neurodegenerative or inflammatory diseases. Increasing interest has been given to NAD+ metabolism during innate and adaptive immune responses suggesting that its modulation could also be relevant during host-pathogen interactions. While the maintenance of NAD+ homeostatic levels assures an adequate environment for host cell survival and proliferation, fluctuations in NAD+ or biosynthetic precursors bioavailability have been described during host-pathogen interactions, which will interfere with pathogen persistence or clearance. Here, we review the double-edged sword of NAD+ metabolism during host-pathogen interactions emphasizing its potential for treatment of infectious diseases. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/46276 |
DOI: | 10.1007/s00018-015-2119-4 |
ISSN: | 1420-682X |
Versão da editora: | http://link.springer.com/journal/18 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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mesquita2015.pdf | 890,57 kB | Adobe PDF | Ver/Abrir |