Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/46276
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Belinha, Ana | por |
dc.contributor.author | Gaifem, Joana | por |
dc.contributor.author | Mesquita, Inês Morais | por |
dc.contributor.author | Silvestre, Ricardo Jorge Leal | por |
dc.date.accessioned | 2017-07-26T10:55:26Z | - |
dc.date.available | 2017-07-26T10:55:26Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1420-682X | por |
dc.identifier.uri | https://hdl.handle.net/1822/46276 | - |
dc.description.abstract | Nicotinamide adenine dinucleotide (NAD+) is a vital molecule found in all living cells. NAD+ intracellular levels are dictated by its synthesis, using the de novo and/or salvage pathway, and through its catabolic use as co-enzyme or co-substrate. The regulation of NAD+ metabolism has proven to be an adequate drug target for several diseases, including cancer, neurodegenerative or inflammatory diseases. Increasing interest has been given to NAD+ metabolism during innate and adaptive immune responses suggesting that its modulation could also be relevant during host-pathogen interactions. While the maintenance of NAD+ homeostatic levels assures an adequate environment for host cell survival and proliferation, fluctuations in NAD+ or biosynthetic precursors bioavailability have been described during host-pathogen interactions, which will interfere with pathogen persistence or clearance. Here, we review the double-edged sword of NAD+ metabolism during host-pathogen interactions emphasizing its potential for treatment of infectious diseases. | por |
dc.description.sponsorship | JG was supported by PD/BD/106053/2015. BV was supported by IRD (Institut de Recherche pour le Développement) institutional funding. JE was supported by a European Community’s Seventh Framework Program under grant agreement No. 602773 (Project KINDRED), an ANR grant (LEISH-APO, France) and a Partenariat Hubert Curien (PHC) (program Volubilis, MA/11/262). JE also thanks the Canada Research Chair program for his support. RS thank FCT—Foundation for Science and Technology—for their Investigator FCT Grant (IF/00021/2014) | por |
dc.language.iso | eng | por |
dc.publisher | Springer | por |
dc.relation | PD/BD/106053/2015 | - |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/602773/EU | - |
dc.rights | openAccess | por |
dc.subject | Nicotinamide adenine dinucleotide (NAD?) | por |
dc.subject | Host-pathogen interaction | por |
dc.subject | NAD?/NADH ratio | por |
dc.subject | NADPH S | por |
dc.subject | Sirtuins | por |
dc.subject | L-tryptophan | por |
dc.subject | NADPH | por |
dc.title | Exploring NAD(+) metabolism in host-pathogen interactions | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://link.springer.com/journal/18 | por |
oaire.citationStartPage | 1225 | por |
oaire.citationEndPage | 1236 | por |
oaire.citationIssue | 6 | por |
oaire.citationTitle | Cellular and Molecular Life Sciences | por |
oaire.citationVolume | 73 | por |
dc.date.updated | 2017-07-20T15:14:09Z | - |
dc.identifier.doi | 10.1007/s00018-015-2119-4 | por |
dc.identifier.pmid | 26718485 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Cellular and Molecular Life Sciences | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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mesquita2015.pdf | 890,57 kB | Adobe PDF | Ver/Abrir |