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https://hdl.handle.net/1822/45158
Título: | Patterns of theta activity in limbic anxiety circuit preceding exploratory behavior in approach-avoidance conflict |
Autor(es): | Jacinto, Luís Ricardo Monteiro Cerqueira, João José Sousa, Nuno |
Palavras-chave: | Anxiety Stress Local field potentials Ventral hippocampus Amygdala Prefrontal cortex |
Data: | 18-Set-2016 |
Editora: | Frontiers Media |
Revista: | Frontiers in Behavioral Neuroscience |
Citação: | Jacinto, L. R., Cerqueira, J. J., & Sousa, N. (2016). Patterns of theta activity in limbic anxiety circuit preceding exploratory behavior in approach-avoidance conflict. [Article]. Frontiers in Behavioral Neuroscience, 10(SEP). doi: 10.3389/fnbeh.2016.00171 |
Resumo(s): | Theta oscillations within the hippocampus-amygdala-medial prefrontal cortex (HPC-AMY-mPFC) circuit have been consistently implicated in the regulation of anxiety behaviors, including risk-assessment. To study if theta activity during risk-assessment was correlated with exploratory behavior in an approach/avoidance paradigm we recorded simultaneous local field potentials from this circuit in rats exploring the elevated-plus maze (FPM). Opposing patterns of power variations in the ventral hippocampus (vHPC), basolateral amygdala (BLA), and prelimbic (PrL) mPFC, but not in the dorsal hippocampus (dHPC), during exploratory risk-assessment of the open arms preceded further exploration of the open arms or retreat back to the safer closed arms. The same patterns of theta power variations in the HPC-BLA-mPFC(PrL) circuit were also displayed by animals submitted to chronic unpredictable stress protocol known to induce an anxious state. Diverging patterns of vHPC-mPFC(PrL) theta coherence were also significantly correlated with forthcoming approach or avoidance behavior in the conflict situation in both controls and stressed animals; interestingly, vHPC-BLA, and BLA-mPFC(PrL) theta coherence correlated with future behavior only in stressed animals, underlying the pivotal role of the amygdala on the stress response. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/45158 |
DOI: | 10.3389/fnbeh.2016.00171 |
ISSN: | 1662-5153 |
Versão da editora: | http://journal.frontiersin.org |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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jacinto, sousa 2016.pdf | 1,83 MB | Adobe PDF | Ver/Abrir |