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https://hdl.handle.net/1822/45158
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Campo DC | Valor | Idioma |
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dc.contributor.author | Jacinto, Luís Ricardo Monteiro | por |
dc.contributor.author | Cerqueira, João José | por |
dc.contributor.author | Sousa, Nuno | por |
dc.date.accessioned | 2017-03-23T16:55:15Z | - |
dc.date.available | 2017-03-23T16:55:15Z | - |
dc.date.issued | 2016-09-18 | - |
dc.date.submitted | 2016 | - |
dc.identifier.citation | Jacinto, L. R., Cerqueira, J. J., & Sousa, N. (2016). Patterns of theta activity in limbic anxiety circuit preceding exploratory behavior in approach-avoidance conflict. [Article]. Frontiers in Behavioral Neuroscience, 10(SEP). doi: 10.3389/fnbeh.2016.00171 | - |
dc.identifier.issn | 1662-5153 | por |
dc.identifier.uri | https://hdl.handle.net/1822/45158 | - |
dc.description.abstract | Theta oscillations within the hippocampus-amygdala-medial prefrontal cortex (HPC-AMY-mPFC) circuit have been consistently implicated in the regulation of anxiety behaviors, including risk-assessment. To study if theta activity during risk-assessment was correlated with exploratory behavior in an approach/avoidance paradigm we recorded simultaneous local field potentials from this circuit in rats exploring the elevated-plus maze (FPM). Opposing patterns of power variations in the ventral hippocampus (vHPC), basolateral amygdala (BLA), and prelimbic (PrL) mPFC, but not in the dorsal hippocampus (dHPC), during exploratory risk-assessment of the open arms preceded further exploration of the open arms or retreat back to the safer closed arms. The same patterns of theta power variations in the HPC-BLA-mPFC(PrL) circuit were also displayed by animals submitted to chronic unpredictable stress protocol known to induce an anxious state. Diverging patterns of vHPC-mPFC(PrL) theta coherence were also significantly correlated with forthcoming approach or avoidance behavior in the conflict situation in both controls and stressed animals; interestingly, vHPC-BLA, and BLA-mPFC(PrL) theta coherence correlated with future behavior only in stressed animals, underlying the pivotal role of the amygdala on the stress response. | por |
dc.description.sponsorship | LJ was supported by fellowships: SFRH/BD/40459/2007 from the Portuguese Foundation for Science and Technology (FCT); UMINHO/BPD/27/2013 funded by CCDR-N and Programa Operational Regiao Norte (ON.2) from QREN/FEDER; and UMINHO/BPD/63/2015 from Fundacao Calouste Gulbenkian funded project (contract grant number P-139977). Financial support for this work was provided by FEDER funds through the Operational Programme Competitiveness Factors - COMPETE and National Funds through FCT under projects ECOMP-01-0124-FEDER-021145, FCT/PTDC/SAU-ENB/118383/2010, FCOMP-01-0124-FEDER-022674 and POCI-01-0145-FEDER-007038; and by the project NORTE-01-0145-FEDER-000013, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). | por |
dc.language.iso | eng | por |
dc.publisher | Frontiers Media | por |
dc.rights | openAccess | por |
dc.subject | Anxiety | por |
dc.subject | Stress | por |
dc.subject | Local field potentials | por |
dc.subject | Ventral hippocampus | por |
dc.subject | Amygdala | por |
dc.subject | Prefrontal cortex | por |
dc.title | Patterns of theta activity in limbic anxiety circuit preceding exploratory behavior in approach-avoidance conflict | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://journal.frontiersin.org | por |
sdum.publicationstatus | info:eu-repo/semantics/publishedVersion | por |
oaire.citationStartPage | 1 | por |
oaire.citationEndPage | 12 | por |
oaire.citationIssue | SEP | por |
oaire.citationTitle | Frontiers in Behavioral Neuroscience | por |
oaire.citationVolume | 10 | por |
dc.date.updated | 2017-02-14T11:35:23Z | - |
dc.identifier.doi | 10.3389/fnbeh.2016.00171 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Frontiers in Behavioral Neuroscience | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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jacinto, sousa 2016.pdf | 1,83 MB | Adobe PDF | Ver/Abrir |