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https://hdl.handle.net/1822/41309
Título: | Anti-inflammatory and antinociceptive activities of Bauhinia monandra leaf lectin |
Autor(es): | Campos, Janaína K. L. Araújo, Chrisjacele S. F. Araújo, Tiago F. S. Santos, Andréa F. S. Teixeira, J. A. Lima, Vera L. M. Coelho, Luana C. B. B. |
Palavras-chave: | Analgesic potential Bauhinia monandra galactose-specific lectin paw edema |
Data: | Jun-2016 |
Editora: | Elsevier 1 |
Revista: | Biochimie |
Citação: | Campos, Janaína K. L.; Araújo, Chrisjacele S. F.; Araújo, Tiago F. S.; Santos, Andréa F. S.; Teixeira, J. A.; Lima, Vera L. M.; Coelho, Luana C. B. B., Anti-inflammatory and antinociceptive activities of Bauhinia monandra leaf lectin. Biochimie Open, 2, 62-68, 2016 |
Resumo(s): | A galactose-specific lectin from Bauhinia monandra leaves (BmoLL) have been purified through ammonium sulphate fractionation followed by guar gel affinity chromatography column. This study aimed to evaluate the potential anti-inflammatory and antinociceptive activity of pure BmoLL in mice. Anti-inflammatory activity was evaluated by 1% carrageenan-induced inflammation in mice treated with BmoLL. Acetic acid-induced abdominal writhing and hot plate methods evaluated antinociceptive activity. BmoLL significantly inhibited the carrageenan-induced paw edema by 47% (30 mg/kg) and 60.5% (60 mg/kg); acetylsalicylic acid (ASA, 100 mg/kg) showed inhibition of 70.5%, in comparison to controls. Leukocyte migration, an immune response to the inflammation process, was significantly reduced in presence of BmoLL; in mice treated with \ASA\ the decrease in leukocyte migration was similar to 15 mg/kg of the lectin. BmoLL at doses of 15, 30 and 60 mg/kg significantly reduced the number of animal contortions by 43.1, 50.1 and 71.3%, respectively.BmoLL leukocyte migration was significantly reduced; in mice treated with \ASA\ the decrease in leukocyte migration was similar to 15 mg/kg of the lectin. BmoLL at doses of 15, 30 and 60 mg/kg significantly reduced the number of animal contortions by 43.1, 50.1 and 71.3%, respectively. The lectin (30 and 60 mg/kg) showed a significant effect in the hot plate assay. BmoLL anti-inflammatory and antinociceptive effects were dose-dependent. The search for new and natural compounds, with minimal side effects, to control pain and inflammation, is constantly increasing. BmoLL has great potential as a natural anti-inflamatory product that can be explored for pharmacological purposes. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/41309 |
DOI: | 10.1016/j.biopen.2016.03.001 |
ISSN: | 2214-0085 |
e-ISSN: | 2214-0085 |
Versão da editora: | http://www.elsevier.com/locate/issn/22140085 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_37866_1.pdf | 436,75 kB | Adobe PDF | Ver/Abrir |