Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/41309
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Campos, Janaína K. L. | por |
dc.contributor.author | Araújo, Chrisjacele S. F. | por |
dc.contributor.author | Araújo, Tiago F. S. | por |
dc.contributor.author | Santos, Andréa F. S. | por |
dc.contributor.author | Teixeira, J. A. | por |
dc.contributor.author | Lima, Vera L. M. | por |
dc.contributor.author | Coelho, Luana C. B. B. | por |
dc.date.accessioned | 2016-04-28T13:20:54Z | - |
dc.date.available | 2016-04-28T13:20:54Z | - |
dc.date.issued | 2016-06 | - |
dc.identifier.citation | Campos, Janaína K. L.; Araújo, Chrisjacele S. F.; Araújo, Tiago F. S.; Santos, Andréa F. S.; Teixeira, J. A.; Lima, Vera L. M.; Coelho, Luana C. B. B., Anti-inflammatory and antinociceptive activities of Bauhinia monandra leaf lectin. Biochimie Open, 2, 62-68, 2016 | por |
dc.identifier.issn | 2214-0085 | por |
dc.identifier.uri | https://hdl.handle.net/1822/41309 | - |
dc.description.abstract | A galactose-specific lectin from Bauhinia monandra leaves (BmoLL) have been purified through ammonium sulphate fractionation followed by guar gel affinity chromatography column. This study aimed to evaluate the potential anti-inflammatory and antinociceptive activity of pure BmoLL in mice. Anti-inflammatory activity was evaluated by 1% carrageenan-induced inflammation in mice treated with BmoLL. Acetic acid-induced abdominal writhing and hot plate methods evaluated antinociceptive activity. BmoLL significantly inhibited the carrageenan-induced paw edema by 47% (30 mg/kg) and 60.5% (60 mg/kg); acetylsalicylic acid (ASA, 100 mg/kg) showed inhibition of 70.5%, in comparison to controls. Leukocyte migration, an immune response to the inflammation process, was significantly reduced in presence of BmoLL; in mice treated with \ASA\ the decrease in leukocyte migration was similar to 15 mg/kg of the lectin. BmoLL at doses of 15, 30 and 60 mg/kg significantly reduced the number of animal contortions by 43.1, 50.1 and 71.3%, respectively.BmoLL leukocyte migration was significantly reduced; in mice treated with \ASA\ the decrease in leukocyte migration was similar to 15 mg/kg of the lectin. BmoLL at doses of 15, 30 and 60 mg/kg significantly reduced the number of animal contortions by 43.1, 50.1 and 71.3%, respectively. The lectin (30 and 60 mg/kg) showed a significant effect in the hot plate assay. BmoLL anti-inflammatory and antinociceptive effects were dose-dependent. The search for new and natural compounds, with minimal side effects, to control pain and inflammation, is constantly increasing. BmoLL has great potential as a natural anti-inflamatory product that can be explored for pharmacological purposes. | por |
dc.description.sponsorship | The authors express their gratitude to the Conselho Nacional de Desenvolvimento Científico e Tecnol ogico (CNPq), for research grants and fellowships (VLML and LCBBC). Also, the Fundaç~ao de Amparo a Ci^encia e Tecnologia do Estado de Pernambuco (FACEPE), and Coordenaç~ao de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) are acknowledged for financial support. In addition, we are grateful to Grant SFRH/ BPD/37349/2007 from the Foundation for Science and Technology and POPH/FSE, awarded to AFSS. | - |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F37349%2F2007/PT | - |
dc.rights | openAccess | por |
dc.subject | Analgesic potential | por |
dc.subject | Bauhinia monandra | por |
dc.subject | galactose-specific lectin | por |
dc.subject | paw edema | por |
dc.title | Anti-inflammatory and antinociceptive activities of Bauhinia monandra leaf lectin | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.elsevier.com/locate/issn/22140085 | por |
dc.comments | CEB37866 | por |
sdum.publicationstatus | info:eu-repo/semantics/publishedVersion | por |
oaire.citationStartPage | 62 | por |
oaire.citationEndPage | 68 | por |
oaire.citationTitle | Biochimie | por |
oaire.citationVolume | 2 | por |
dc.date.updated | 2016-04-27T13:41:10Z | - |
dc.identifier.eissn | 2214-0085 | - |
dc.identifier.doi | 10.1016/j.biopen.2016.03.001 | por |
sdum.journal | Biochimie | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
document_37866_1.pdf | 436,75 kB | Adobe PDF | Ver/Abrir |